Aprepitant M2 Metabolite (1R,2R,3S)-Isomer

Name: Aprepitant M2 Metabolite (1R,2R,3S)-Isomer
Brand: Vaqora Chemicals
SKU: VQ-029207

About Aprepitant M2 Metabolite (1R,2R,3S)-Isomer

Aprepitant M2 Metabolite (1R,2R,3S)-Isomer (CAS 171338-27-5) is a metabolite or degradation product of Aprepitant offered by Vaqora Chemicals. The compound has the formula C20H18F7NO2, corresponding to a molecular weight of 437.4 g/mol. Its systematic (IUPAC) name is (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine. Common synonyms include Aprepitant M2 and Aprepitant-M2.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Aprepitant, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Aprepitant

View every impurity, metabolite and intermediate we list for Aprepitant.

Aprepitant impurities

Specifications & identifiers

Chemical identifiers
Product name	Aprepitant M2 Metabolite (1R,2R,3S)-Isomer
Catalogue No.	VQ-029207
CAS Number	171338-27-5
IUPAC name	(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
Molecular formula	C₂₀H₁₈F₇NO₂
Molecular weight	437.4 g/mol
Exact mass	437.1226
Grade	Reference Standard
HSN code	38229090
InChIKey	AFBDSAJOMZYQAI-CNOZUTPLSA-N
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](NCCO2)C3=CC=C(C=C3)F
PubChem CID	10113945

Physical properties
Physical form	Solid
LogP (XLogP3)	4.7
H-bond donors / acceptors	1 / 10
TPSA	30.5 Å²
Synonyms	2-((1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholine, (2R,3S)-, (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine, 2-(r)-[1-(r)-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(s)-fluorophenylmorpholine, Aprepitant M2, Aprepitant-M2, (2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholine, [Aprepitant-M2], Fosaprepitant Impurity C, (2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine, (2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-(2R,3S)-morpholine

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Aprepitant M2 Metabolite (1R,2R,3S)-Isomer?

The CAS Registry Number of Aprepitant M2 Metabolite (1R,2R,3S)-Isomer is 171338-27-5. It is also known as 2-((1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholine, (2R,3S)-, (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine, 2-(r)-[1-(r)-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(s)-fluorophenylmorpholine.

What is the molecular formula and molecular weight of Aprepitant M2 Metabolite (1R,2R,3S)-Isomer?

Aprepitant M2 Metabolite (1R,2R,3S)-Isomer has the molecular formula C20H18F7NO2 and a molecular weight of 437.4 g/mol. Its IUPAC name is (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine.

What is Aprepitant M2 Metabolite (1R,2R,3S)-Isomer used for?

Aprepitant M2 Metabolite (1R,2R,3S)-Isomer is supplied as a characterised reference material related to Aprepitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Aprepitant M2 Metabolite (1R,2R,3S)-Isomer can I order?

We supply Aprepitant M2 Metabolite (1R,2R,3S)-Isomer in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Aprepitant M2 Metabolite (1R,2R,3S)-Isomer?

Yes. Every lot of Aprepitant M2 Metabolite (1R,2R,3S)-Isomer is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Aprepitant M2 Metabolite (1R,2R,3S)-Isomer be shipped internationally?

Yes. We export Aprepitant M2 Metabolite (1R,2R,3S)-Isomer worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.