Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hy… 1333998-21-2

Name: Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-047437

About Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride

Listed under CAS 1333998-21-2, Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride is a metabolite or degradation product of Aprepitant available from Vaqora Chemicals. The compound has the formula C20H19ClF7NO2, corresponding to a molecular weight of 473.8 g/mol. Common synonyms include Aprepitant Impurity H and Aprepitant Impurity 21.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Aprepitant, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Aprepitant

View every impurity, metabolite and intermediate we list for Aprepitant.

Aprepitant impurities

Specifications & identifiers

Chemical identifiers
Product name	Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride
Catalogue No.	VQ-047437
CAS Number	1333998-21-2
IUPAC name	(2R,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine;hydrochloride
Molecular formula	C₂₀H₁₉ClF₇NO₂
Molecular weight	473.8 g/mol
Exact mass	473.0993
Grade	Reference Standard
HSN code	38229090
InChIKey	DWCCMKXSGCKMJF-XPAAWDOWSA-N
SMILES	C[C@@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@H](NCCO2)C3=CC=C(C=C3)F.Cl
PubChem CID	46868136

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 10
TPSA	30.5 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride?

The CAS Registry Number of Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride is 1333998-21-2. It is also known as Des-1,2,4-triazol-3-one-5-methyl (2R,3R,2-(S))-Aprepitant Hydrochloride, Aprepitant Impurity H, Aprepitant Impurity 21.

What is the molecular formula and molecular weight of Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride?

Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride has the molecular formula C20H19ClF7NO2 and a molecular weight of 473.8 g/mol.

What is Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride used for?

Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride is supplied as a characterised reference material related to Aprepitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride can I order?

We supply Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride?

Yes. Every lot of Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride be shipped internationally?

Yes. We export Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.