Axitinib Sulfonyl Impurity

Name: Axitinib Sulfonyl Impurity
Brand: Vaqora Chemicals
SKU: VQ-021688

About Axitinib Sulfonyl Impurity

Listed under CAS 1348536-59-3, Axitinib Sulfonyl Impurity is an impurity of Axitinib available from Vaqora Chemicals. Its molecular formula is C22H18N4O3S and its molecular weight is 418.5 g/mol. Systematically, it is named N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfonyl]benzamide. Alternative names: Axitinib Sulfone and Axitinib Sulfone Impurity.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

This Axitinib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Axitinib Sulfonyl Impurity in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Axitinib

View every impurity, metabolite and intermediate we list for Axitinib.

Axitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Axitinib Sulfonyl Impurity
Catalogue No.	VQ-021688
CAS Number	1348536-59-3
IUPAC name	N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfonyl]benzamide
Molecular formula	C₂₂H₁₈N₄O₃S
Molecular weight	418.5 g/mol
Exact mass	418.11
Grade	Reference Standard
HSN code	38229090
InChIKey	UDHVZPNZJDOMGL-FMIVXFBMSA-N
SMILES	CNC(=O)C1=CC=CC=C1S(=O)(=O)C2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
PubChem CID	91810706

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	2 / 5
TPSA	113 Å²
Synonyms	Axitinib Sulfone, Axitinib Sulfone Impurity, Sulfonyl axitinib, Axitinib metabolite M15, N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide, Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)sulfonyl)-, N-Methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)sulfonyl)benzamide, N-methyl-2-((3-((E)-2-pyridin-2-ylethenyl)-1H-indazol-6-yl)sulfonyl)benzamide, Axitinib Impurity B, (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfonyl)benzamide, N-methyl-2-[[3-[(E)-2-(2-pyridyl)vinyl]-1H-indazol-6-yl]sulfonyl]benzamide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Axitinib Sulfonyl Impurity?

The CAS Registry Number of Axitinib Sulfonyl Impurity is 1348536-59-3. It is also known as Axitinib Sulfone, Axitinib Sulfone Impurity, Sulfonyl axitinib.

What is the molecular formula and molecular weight of Axitinib Sulfonyl Impurity?

Axitinib Sulfonyl Impurity has the molecular formula C22H18N4O3S and a molecular weight of 418.5 g/mol. Its IUPAC name is N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfonyl]benzamide.

What is Axitinib Sulfonyl Impurity used for?

Axitinib Sulfonyl Impurity is supplied as a characterised reference material related to Axitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Axitinib Sulfonyl Impurity can I order?

We supply Axitinib Sulfonyl Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Axitinib Sulfonyl Impurity?

Yes. Every lot of Axitinib Sulfonyl Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Axitinib Sulfonyl Impurity be shipped internationally?

Yes. Axitinib Sulfonyl Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.