Axitinib Sulfoxide

Name: Axitinib Sulfoxide
Brand: Vaqora Chemicals
SKU: VQ-021687

About Axitinib Sulfoxide

Listed under CAS 1347304-18-0, Axitinib Sulfoxide is a metabolite or degradation product of Axitinib available from Vaqora Chemicals. The compound has the formula C22H18N4O2S, corresponding to a molecular weight of 402.5 g/mol. Systematically, it is named N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide. It is also known as Axitinib metabolite M12.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Axitinib, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Axitinib Sulfoxide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Axitinib

View every impurity, metabolite and intermediate we list for Axitinib.

Axitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Axitinib Sulfoxide
Catalogue No.	VQ-021687
CAS Number	1347304-18-0
IUPAC name	N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
Molecular formula	C₂₂H₁₈N₄O₂S
Molecular weight	402.5 g/mol
Exact mass	402.115
Grade	Reference Standard
HSN code	38229090
InChIKey	MAHSNFBPPYMWFB-FMIVXFBMSA-N
SMILES	CNC(=O)C1=CC=CC=C1S(=O)C2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
PubChem CID	86278350

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	2 / 5
TPSA	107 Å²
Synonyms	Axitinib metabolite M12, Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)sulfinyl), N-methyl-2-((3-((E)-2-pyridin-2-ylethenyl)-1H-indazol-6-yl)sulfinyl)benzamide, N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide, N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide, N-methyl-2-[[3-[(E)-2-(2-pyridyl)vinyl]-1H-indazol-6-yl]sulfinyl]benzamide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Axitinib Sulfoxide?

The CAS Registry Number of Axitinib Sulfoxide is 1347304-18-0. It is also known as Axitinib metabolite M12, Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)sulfinyl), N-methyl-2-((3-((E)-2-pyridin-2-ylethenyl)-1H-indazol-6-yl)sulfinyl)benzamide.

What is the molecular formula and molecular weight of Axitinib Sulfoxide?

Axitinib Sulfoxide has the molecular formula C22H18N4O2S and a molecular weight of 402.5 g/mol. Its IUPAC name is N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide.

What is Axitinib Sulfoxide used for?

Axitinib Sulfoxide is supplied as a characterised reference material related to Axitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Axitinib Sulfoxide can I order?

We supply Axitinib Sulfoxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Axitinib Sulfoxide?

Yes. Every lot of Axitinib Sulfoxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Axitinib Sulfoxide be shipped internationally?

Yes. Axitinib Sulfoxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.