Clobetasol Propionate EP Impurity B

Name: Clobetasol Propionate EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-022221

About Clobetasol Propionate EP Impurity B

Vaqora Chemicals supplies Clobetasol Propionate EP Impurity B, a pharmacopeial impurity of Clobetasol registered under CAS number 1356190-17-4. The compound has the formula C22H26ClFO3, corresponding to a molecular weight of 392.9 g/mol. Common synonyms include Clobetasol Propionate - Impurity B and Clobetasol Propionate Impurity B.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 3 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Clobetasol, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Clobetasol Propionate EP Impurity B in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Clobetasol

View every impurity, metabolite and intermediate we list for Clobetasol.

Clobetasol impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Clobetasol Propionate EP Impurity B
Catalogue No.	VQ-022221
CAS Number	1356190-17-4
IUPAC name	(8S,9R,10S,11S,13S,14S)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-3-one
Molecular formula	C₂₂H₂₆ClFO₃
Molecular weight	392.9 g/mol
Exact mass	392.1555
Grade	Reference Standard
HSN code	38229090
InChIKey	YWRGNRUKHBYFTD-QEYSUVLUSA-N
SMILES	CC1=C([C@]2(C[C@@H]([C@]3([C@H]([C@@H]2C1)CCC4=CC(=O)C=C[C@@]43C)F)O)C)C(=O)CCl
PubChem CID	13067007

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 4
TPSA	54.4 Å²
Synonyms	Clobetasol Propionate - Impurity B, (11beta)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione, 21-Chloro-9-fluoro-11beta-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione, Pregna-1,4,16-triene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-, (11beta)-, Clobetasol Propionate Impurity B, (11, A)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P260, P273, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Clobetasol Propionate EP Impurity B?

The CAS Registry Number of Clobetasol Propionate EP Impurity B is 1356190-17-4. It is also known as Clobetasol Propionate - Impurity B, (11beta)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione, 21-Chloro-9-fluoro-11beta-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione.

What is the molecular formula and molecular weight of Clobetasol Propionate EP Impurity B?

Clobetasol Propionate EP Impurity B has the molecular formula C22H26ClFO3 and a molecular weight of 392.9 g/mol. Its IUPAC name is (8S,9R,10S,11S,13S,14S)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-3-one.

What is Clobetasol Propionate EP Impurity B used for?

Clobetasol Propionate EP Impurity B is supplied as a characterised reference material related to Clobetasol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Clobetasol Propionate EP Impurity B can I order?

We supply Clobetasol Propionate EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Clobetasol Propionate EP Impurity B?

Yes. Every lot of Clobetasol Propionate EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Clobetasol Propionate EP Impurity B be shipped internationally?

Yes. Clobetasol Propionate EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.