Clozapine

Name: Clozapine
Brand: Vaqora Chemicals
SKU: VQ-022249

About Clozapine

Clozapine is a high-purity reference standard of Clozapine carrying the CAS registry number 5786-21-0. With the molecular formula C18H19ClN4, it has a molar mass of 326.8 g/mol. Systematically, it is named 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine. Alternative names: Clozapine Resolution Mixture and Clozapin.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Clozapine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Clozapine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Specifications & identifiers

Chemical identifiers
Product name	Clozapine
Catalogue No.	VQ-022249
CAS Number	5786-21-0
IUPAC name	3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular formula	C₁₈H₁₉ClN₄
Molecular weight	326.8 g/mol
Exact mass	326.1298
Grade	Reference Standard
HSN code	38229090
InChIKey	QZUDBNBUXVUHMW-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
PubChem CID	135398737

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 3
TPSA	30.9 Å²
Synonyms	Clozapine Resolution Mixture, Clozapin, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, Fazaclo ODT, 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, Clozapine (udl), Clozapine (ivax), Clozapine (teva), Clozapine (mylan), Clozapine (caraco), Clozapine (fazaclo)

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Clozapine?

The CAS Registry Number of Clozapine is 5786-21-0. It is also known as Clozapine Resolution Mixture, Clozapin, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.

What is the molecular formula and molecular weight of Clozapine?

Clozapine has the molecular formula C18H19ClN4 and a molecular weight of 326.8 g/mol. Its IUPAC name is 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine.

What is Clozapine used for?

Clozapine is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Clozapine can I order?

We supply Clozapine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Clozapine?

Yes. Every lot of Clozapine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Clozapine be shipped internationally?

Yes. Clozapine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.