Dabrafenib

Name: Dabrafenib
Brand: Vaqora Chemicals
SKU: VQ-007404

About Dabrafenib

Listed under CAS 1195765-45-7, Dabrafenib is a high-purity reference standard of Dabrafenib available from Vaqora Chemicals. Formula C23H20F3N5O2S2, molecular weight 519.6 g/mol. Systematically, it is named N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide. It is also known as BRAF Inhibitor GSK2118436 or Dabrafenib (GSK2118436).

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Dabrafenib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Dabrafenib

View every impurity, metabolite and intermediate we list for Dabrafenib.

Dabrafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Dabrafenib
Catalogue No.	VQ-007404
CAS Number	1195765-45-7
Other CAS	1195768-06-9
IUPAC name	N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Molecular formula	C₂₃H₂₀F₃N₅O₂S₂
Molecular weight	519.6 g/mol
Exact mass	519.1011
Grade	Reference Standard
HSN code	38229090
InChIKey	BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
PubChem CID	44462760

Physical properties
Physical form	Solid
LogP (XLogP3)	4.8
H-bond donors / acceptors	2 / 11
TPSA	147 Å²
Synonyms	BRAF Inhibitor GSK2118436, Dabrafenib (GSK2118436), Dabrafenib (Free Base), Dabrafenib (USAN), 1195765-45-7 (free base), Dabrafenib (Standard), EX-A1320

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dabrafenib?

The CAS Registry Number of Dabrafenib is 1195765-45-7. It is also known as BRAF Inhibitor GSK2118436, Dabrafenib (GSK2118436), Dabrafenib (Free Base).

What is the molecular formula and molecular weight of Dabrafenib?

Dabrafenib has the molecular formula C23H20F3N5O2S2 and a molecular weight of 519.6 g/mol. Its IUPAC name is N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide.

What is Dabrafenib used for?

Dabrafenib is supplied as a characterised reference material related to Dabrafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dabrafenib can I order?

We supply Dabrafenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dabrafenib?

Yes. Every lot of Dabrafenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dabrafenib be shipped internationally?

Yes. Dabrafenib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.