Entecavir EP Impurity A

Name: Entecavir EP Impurity A
Brand: Vaqora Chemicals
SKU: VQ-030492

About Entecavir EP Impurity A

Entecavir EP Impurity A is a pharmacopeial impurity of Entecavir carrying the CAS registry number 1367369-78-5. With the molecular formula C12H15N5O3, it has a molar mass of 277.28 g/mol. The IUPAC name is 2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one. It is also known as Entecavir 1-epimer or 1R,3R,4S Entecavir.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Entecavir, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Entecavir EP Impurity A is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Entecavir

View every impurity, metabolite and intermediate we list for Entecavir.

Entecavir impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Entecavir EP Impurity A
Catalogue No.	VQ-030492
CAS Number	1367369-78-5
IUPAC name	2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one
Molecular formula	C₁₂H₁₅N₅O₃
Molecular weight	277.28 g/mol
Exact mass	277.1175
Grade	Reference Standard
HSN code	38229090
InChIKey	QDGZDCVAUDNJFG-RNJXMRFFSA-N
SMILES	C=C1[C@@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N
PubChem CID	135743573

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.3
H-bond donors / acceptors	4 / 5
TPSA	126 Å²
Synonyms	Entecavir 1-epimer, 1R,3R,4S Entecavir, Entecavir Monohydrate - Impurity A, 9-((1R,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine, 1'-epi-Entecavir, Entecavir Impurity A, Entecavir Impurity 126 (1R,3R,4S)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H351Suspected of causing cancer

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Entecavir EP Impurity A?

The CAS Registry Number of Entecavir EP Impurity A is 1367369-78-5. It is also known as Entecavir 1-epimer, 1R,3R,4S Entecavir, Entecavir Monohydrate - Impurity A.

What is the molecular formula and molecular weight of Entecavir EP Impurity A?

Entecavir EP Impurity A has the molecular formula C12H15N5O3 and a molecular weight of 277.28 g/mol. Its IUPAC name is 2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one.

What is Entecavir EP Impurity A used for?

Entecavir EP Impurity A is supplied as a characterised reference material related to Entecavir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Entecavir EP Impurity A can I order?

We supply Entecavir EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Entecavir EP Impurity A?

Yes. Every lot of Entecavir EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Entecavir EP Impurity A be shipped internationally?

Yes. Entecavir EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.