Hydrochlorothiazide EP Impurity B

Name: Hydrochlorothiazide EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-021133

About Hydrochlorothiazide EP Impurity B

Vaqora Chemicals supplies Hydrochlorothiazide EP Impurity B, a pharmacopeial impurity of Hydrochlorothiazide registered under CAS number 121-30-2. Formula C6H8ClN3O4S2, molecular weight 285.7 g/mol. Systematically, it is named 4-amino-6-chlorobenzene-1,3-disulfonamide. Alternative names: 4-Amino-6-chloro-1,3-benzenedisulfonamide and Hydrochlorothiazide - Impurity B.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Hydrochlorothiazide to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Hydrochlorothiazide EP Impurity B in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Hydrochlorothiazide

View every impurity, metabolite and intermediate we list for Hydrochlorothiazide.

Hydrochlorothiazide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Hydrochlorothiazide EP Impurity B
Catalogue No.	VQ-021133
CAS Number	121-30-2
IUPAC name	4-amino-6-chlorobenzene-1,3-disulfonamide
Molecular formula	C₆H₈ClN₃O₄S₂
Molecular weight	285.7 g/mol
Exact mass	284.9645
Grade	Reference Standard
HSN code	38229090
InChIKey	IHJCXVZDYSXXFT-UHFFFAOYSA-N
SMILES	C1=C(C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N)N
PubChem CID	67136

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.5
H-bond donors / acceptors	3 / 7
TPSA	163 Å²
Synonyms	4-Amino-6-chloro-1,3-benzenedisulfonamide, Hydrochlorothiazide - Impurity B, Hydrochlorothiazide Impurity B, Chloraminophenamide, Altizide EP Impurity A, Chloroaminophenamide, 1,3-Benzenedisulfonamide, 4-amino-6-chloro-, 3-Chloro-4,6-disulfamoylaniline, 5-Chloro-2,4-disulfamoylaniline, m-Benzenedisulfonamide, 4-amino-6-chloro-, 4-amino-6-chloro-benzene-1,3-disulfonamide, 2-Amino-4-chloro-m-benzenedisulfonamide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Hydrochlorothiazide EP Impurity B?

The CAS Registry Number of Hydrochlorothiazide EP Impurity B is 121-30-2. It is also known as 4-Amino-6-chloro-1,3-benzenedisulfonamide, Hydrochlorothiazide - Impurity B, Hydrochlorothiazide Impurity B.

What is the molecular formula and molecular weight of Hydrochlorothiazide EP Impurity B?

Hydrochlorothiazide EP Impurity B has the molecular formula C6H8ClN3O4S2 and a molecular weight of 285.7 g/mol. Its IUPAC name is 4-amino-6-chlorobenzene-1,3-disulfonamide.

What is Hydrochlorothiazide EP Impurity B used for?

Hydrochlorothiazide EP Impurity B is supplied as a characterised reference material related to Hydrochlorothiazide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Hydrochlorothiazide EP Impurity B can I order?

We supply Hydrochlorothiazide EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Hydrochlorothiazide EP Impurity B?

Yes. Every lot of Hydrochlorothiazide EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Hydrochlorothiazide EP Impurity B be shipped internationally?

Yes. Hydrochlorothiazide EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.