Hydrocortisone-d4

Name: Hydrocortisone-d4
Brand: Vaqora Chemicals
SKU: VQ-031100

About Hydrocortisone-d4

Hydrocortisone-d4 is a stable isotope labelled analogue related to Hydrocortisone carrying the CAS registry number 73565-87-4. Formula C21H30O5, molecular weight 366.5 g/mol. Alternative names: Cortisol-9,11,12,12-d4 and Hydrocortisone-9,11,12,12-d4.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Hydrocortisone and related analytes in bioanalytical, pharmacokinetic and impurity studies. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Hydrocortisone-d4 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Hydrocortisone

View every impurity, metabolite and intermediate we list for Hydrocortisone.

Hydrocortisone impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Hydrocortisone-d4
Catalogue No.	VQ-031100
CAS Number	73565-87-4
IUPAC name	(8S,10R,11S,13S)-9,11,12,12-tetradeuterio-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Molecular formula	C₂₁H₃₀O₅
Molecular weight	366.5 g/mol
Exact mass	366.2344
Grade	Reference Standard
HSN code	38229090
InChIKey	JYGXADMDTFJGBT-LTVXCZLVSA-N
SMILES	[2H][C@@]1(C([C@]2(C(CCC2(C(=O)CO)O)[C@H]3C1([C@]4(CCC(=O)C=C4CC3)C)[2H])C)([2H])[2H])O
PubChem CID	46781064

Physical properties
Physical form	Solid
LogP (XLogP3)	1.6
H-bond donors / acceptors	3 / 5
TPSA	94.8 Å²

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Hydrocortisone-d4?

The CAS Registry Number of Hydrocortisone-d4 is 73565-87-4. It is also known as (9xi,11beta,14xi,17xi)-11,17,21-Trihydroxy(9,11,12,12-~2~H_4_)pregn-4-ene-3,20-dione, Cortisol-9,11,12,12-d4, Hydrocortisone-9,11,12,12-d4.

What is the molecular formula and molecular weight of Hydrocortisone-d4?

Hydrocortisone-d4 has the molecular formula C21H30O5 and a molecular weight of 366.5 g/mol. Its IUPAC name is (8S,10R,11S,13S)-9,11,12,12-tetradeuterio-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one.

What is Hydrocortisone-d4 used for?

Hydrocortisone-d4 is supplied as a characterised reference material related to Hydrocortisone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Hydrocortisone-d4 can I order?

We supply Hydrocortisone-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Hydrocortisone-d4?

Yes. Every lot of Hydrocortisone-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Hydrocortisone-d4 be shipped internationally?

Yes. Hydrocortisone-d4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.