Lapatinib

Name: Lapatinib
Brand: Vaqora Chemicals
SKU: VQ-026364

About Lapatinib

Lapatinib is a high-purity reference standard of Lapatinib carrying the CAS registry number 231277-92-2. Formula C29H26ClFN4O4S, molecular weight 581.1 g/mol. Alternative names: Lapatinib free base and Lapatinib (free base).

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Lapatinib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Lapatinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Lapatinib

View every impurity, metabolite and intermediate we list for Lapatinib.

Lapatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Lapatinib
Catalogue No.	VQ-026364
CAS Number	231277-92-2
IUPAC name	N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
Molecular formula	C₂₉H₂₆ClFN₄O₄S
Molecular weight	581.1 g/mol
Exact mass	580.1347
Grade	Reference Standard
HSN code	38229090
InChIKey	BCFGMOOMADDAQU-UHFFFAOYSA-N
SMILES	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
PubChem CID	208908

Physical properties
Physical form	Solid
LogP (XLogP3)	5.1
H-bond donors / acceptors	2 / 9
TPSA	115 Å²
Synonyms	Lapatinib free base, Lapatinib (free base), Lapatinib base, 1xkk, Kinome_3685, Lapatinib (GW572016), Lapatinib, Free base, nchembio866-comp20, Kinome_3684, EX-A402

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H319Causes serious eye irritation
H362May cause harm to breast-fed children
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P260, P263, P264, P264 + P265, P270, P273, P280, P305 + P351 + P338, P318, P337 + P317, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Lapatinib?

The CAS Registry Number of Lapatinib is 231277-92-2. It is also known as Lapatinib free base, Lapatinib (free base), Lapatinib base.

What is the molecular formula and molecular weight of Lapatinib?

Lapatinib has the molecular formula C29H26ClFN4O4S and a molecular weight of 581.1 g/mol. Its IUPAC name is N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine.

What is Lapatinib used for?

Lapatinib is supplied as a characterised reference material related to Lapatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Lapatinib can I order?

We supply Lapatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Lapatinib?

Yes. Every lot of Lapatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Lapatinib be shipped internationally?

Yes. Lapatinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.