Leflunomide

Name: Leflunomide
Brand: Vaqora Chemicals
SKU: VQ-022937

About Leflunomide

Leflunomide is a high-purity reference standard of Leflunomide carrying the CAS registry number 75706-12-6. Formula C12H9F3N2O2, molecular weight 270.21 g/mol. Its systematic (IUPAC) name is 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide. Alternative names: Leflunomide Form 1 and HWA-486.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Leflunomide, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Leflunomide in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Leflunomide

View every impurity, metabolite and intermediate we list for Leflunomide.

Leflunomide impurities

Specifications & identifiers

Chemical identifiers
Product name	Leflunomide
Catalogue No.	VQ-022937
CAS Number	75706-12-6
IUPAC name	5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Molecular formula	C₁₂H₉F₃N₂O₂
Molecular weight	270.21 g/mol
Exact mass	270.0616
Grade	Reference Standard
HSN code	38229090
InChIKey	VHOGYURTWQBHIL-UHFFFAOYSA-N
SMILES	CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
PubChem CID	3899

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	1 / 6
TPSA	55.1 Å²
Synonyms	Leflunomide Form 1, HWA-486, leflunomide medac, Leflunomide teva, 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide, SU-101, Leflunomide winthrop, Leflunomide ratiopharm, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide, alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide, 4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Leflunomide?

The CAS Registry Number of Leflunomide is 75706-12-6. It is also known as Leflunomide Form 1, HWA-486, leflunomide medac.

What is the molecular formula and molecular weight of Leflunomide?

Leflunomide has the molecular formula C12H9F3N2O2 and a molecular weight of 270.21 g/mol. Its IUPAC name is 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide.

What is Leflunomide used for?

Leflunomide is supplied as a characterised reference material related to Leflunomide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Leflunomide can I order?

We supply Leflunomide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Leflunomide?

Yes. Every lot of Leflunomide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Leflunomide be shipped internationally?

Yes. Leflunomide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.