Loperamide N-Oxide

Name: Loperamide N-Oxide
Brand: Vaqora Chemicals
SKU: VQ-007193

About Loperamide N-Oxide

Loperamide N-Oxide (CAS 217471-03-9) is a metabolite or degradation product of Loperamide offered by Vaqora Chemicals at a purity of 98.40%. Formula C29H33ClN2O3, molecular weight 493.0 g/mol. Its systematic (IUPAC) name is 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide. Alternative names: Loperamide oxide and trans-Loperamide N-Oxide.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Loperamide, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Loperamide N-Oxide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Loperamide

View every impurity, metabolite and intermediate we list for Loperamide.

Loperamide impurities

Specifications & identifiers

Chemical identifiers
Product name	Loperamide N-Oxide
Catalogue No.	VQ-007193
CAS Number	217471-03-9
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Molecular formula	C₂₉H₃₃ClN₂O₃
Molecular weight	493 g/mol
Exact mass	492.218
Grade	Reference Standard
Purity / assay	98.40%
HSN code	38229090
InChIKey	KXVSBTJVTUVNPM-UHFFFAOYSA-N
SMILES	CN(C)C(=O)C(CC[N+]1(CCC(CC1)(C2=CC=C(C=C2)Cl)O)[O-])(C3=CC=CC=C3)C4=CC=CC=C4
PubChem CID	71421

Physical properties
Physical form	Solid
LogP (XLogP3)	4.5
H-bond donors / acceptors	1 / 3
TPSA	58.6 Å²
Synonyms	Loperamide oxide, trans-Loperamide N-Oxide, Arestal, Loperamide oxyde, Loperamide oxide anhydrous, Oxido de loperamida, Loperamide oxide anhydrous, cis-, Loperamide oxide (INN), Loperamidum oxidum, trans-N-Oxide of loperamide, cis-loperamide oxide, Loperamide oxide monohydrate CRS

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Loperamide N-Oxide?

The CAS Registry Number of Loperamide N-Oxide is 217471-03-9. It is also known as Loperamide oxide, trans-Loperamide N-Oxide, Arestal.

What is the molecular formula and molecular weight of Loperamide N-Oxide?

Loperamide N-Oxide has the molecular formula C29H33ClN2O3 and a molecular weight of 493 g/mol. Its IUPAC name is 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide.

What is Loperamide N-Oxide used for?

Loperamide N-Oxide is supplied as a characterised reference material related to Loperamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Loperamide N-Oxide can I order?

We supply Loperamide N-Oxide in Reference Standard (98.40%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Loperamide N-Oxide?

Yes. Every lot of Loperamide N-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Loperamide N-Oxide be shipped internationally?

Yes. Loperamide N-Oxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.