Methotrexate hydrate, ≥98% (HPLC), powder

Name: Methotrexate hydrate, ≥98% (HPLC), powder
Brand: Vaqora Chemicals
SKU: VQ-011979

About Methotrexate hydrate, ≥98% (HPLC), powder

Vaqora Chemicals supplies Methotrexate hydrate, a diazine derivative registered under CAS number 133073-73-1 with a typical assay of ≥98%. The compound has the formula C20H24N8O6, corresponding to a molecular weight of 472.5 g/mol. Its systematic (IUPAC) name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. Hydrate. It is also known as Methylaminopter or Methotrexate monohydrate.

The material typically appears as a yellow to yellow-orange powder. Key physical data: a melting point of 185-204 °C. Store it at 2–8 °C, in a tightly closed container. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is commonly used for organic synthesis and API synthesis. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Methotrexate hydrate in 10 mg, 25 mg, 100 mg and 500 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Organic synthesis
API synthesis

Industries

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate hydrate, ≥98% (HPLC), powder
Catalogue No.	VQ-011979
CAS Number	133073-73-1
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate
Molecular formula	C₂₀H₂₄N₈O₆
Molecular weight	472.5 g/mol
Exact mass	472.1819
Purity / assay	≥98%
HSN code	29339900
InChIKey	FPJYMUQSRFJSEW-ZOWNYOTGSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O
PubChem CID	165528

Physical properties
Physical form	Powder
Appearance	Yellow to yellow-orange powder
Melting point	185-204 °C
H-bond donors / acceptors	6 / 13
TPSA	212 Å²
Storage	2–8 °C
Synonyms	Methylaminopter, Methotrexate monohydrate, Methotrexate hydrate(1:x), Methotrexate xhydrate, Methotrexate (monohydrate), (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid hydrate, L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [CAS], Methotrexate (hydrate), Methotrexate hydrate, Vetec(TM) reagent grade, 98%, Methotrexate trihydrate, Antifolan hydrate, (4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid hydrate(1:x)

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate hydrate, ≥98% (HPLC), powder?

The CAS Registry Number of Methotrexate hydrate, ≥98% (HPLC), powder is 133073-73-1. It is also known as Methylaminopter, Methotrexate monohydrate, Methotrexate hydrate(1:x).

What is the molecular formula and molecular weight of Methotrexate hydrate, ≥98% (HPLC), powder?

Methotrexate hydrate, ≥98% (HPLC), powder has the molecular formula C20H24N8O6 and a molecular weight of 472.5 g/mol.

Which grade and pack sizes of Methotrexate hydrate, ≥98% (HPLC), powder can I order?

We supply Methotrexate hydrate, ≥98% (HPLC), powder in (≥98%) grade, in 10 mg, 25 mg, 100 mg, 500 mg, 1 g, 25 g packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate hydrate, ≥98% (HPLC), powder?

Yes. Every lot of Methotrexate hydrate, ≥98% (HPLC), powder is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate hydrate, ≥98% (HPLC), powder be shipped internationally?

Yes. Methotrexate hydrate, ≥98% (HPLC), powder is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.

How should Methotrexate hydrate, ≥98% (HPLC), powder be stored?

2–8 °C. Keep the container tightly closed and refer to the SDS for full handling guidance.