Methotrexate, 98%

Name: Methotrexate, 98%
Brand: Vaqora Chemicals
SKU: VQ-011980

About Methotrexate, 98%

Listed under CAS 59-05-2, Methotrexate is a diazine derivative available from Vaqora Chemicals at a purity of 98%. With the molecular formula C20H22N8O5, it has a molar mass of 454.4 g/mol. Systematically, it is named (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. Alternative names: (+)-Amethopterin hydrate and Amethopterin.

In its supplied form it is a light yellow to brown powder. Store it at 2–8 °C, in a tightly closed container. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

It is commonly used for organic synthesis and API synthesis. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 100 mg, 1 g and 5 g, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Organic synthesis
API synthesis

Industries

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate, 98%
Catalogue No.	VQ-011980
CAS Number	59-05-2
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₅
Molecular weight	454.4 g/mol
Exact mass	454.1713
Purity / assay	98%
HSN code	29420090
InChIKey	FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	126941

Physical properties
Physical form	Powder
Appearance	Light yellow to brown powder
LogP (XLogP3)	-1.8
H-bond donors / acceptors	5 / 12
TPSA	211 Å²
Storage	2–8 °C
Synonyms	(+)-Amethopterin hydrate, Amethopterin, Ledertrexate, Emtexate, L-Amethopterin, Amethopterine, Medsatrexate, Methoblastin, Methotextrate, Brimexate, Emthexate, Texate

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 59-05-2

IP/BP/USP

Methotrexate

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

VQ-004219

Reference Standard

Methotrexate

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

VQ-007576

Frequently asked questions

What is the CAS number of Methotrexate, 98%?

The CAS Registry Number of Methotrexate, 98% is 59-05-2. It is also known as (+)-Amethopterin hydrate, Amethopterin, Ledertrexate.

What is the molecular formula and molecular weight of Methotrexate, 98%?

Methotrexate, 98% has the molecular formula C20H22N8O5 and a molecular weight of 454.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid.

Which grade and pack sizes of Methotrexate, 98% can I order?

We supply Methotrexate, 98% in (98%) grade, in 100 mg, 1 g, 5 g packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate, 98%?

Yes. Every lot of Methotrexate, 98% is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate, 98% be shipped internationally?

Yes. Methotrexate, 98% is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.

How should Methotrexate, 98% be stored?

2–8 °C. Keep the container tightly closed and refer to the SDS for full handling guidance.