Monomethylauristatin E

Name: Monomethylauristatin E
Brand: Vaqora Chemicals
SKU: VQ-030258

About Monomethylauristatin E

Monomethylauristatin E is an impurity of Auristatin carrying the CAS registry number 474645-27-7. Its molecular formula is C39H67N5O7 and its molecular weight is 718.0 g/mol. Common synonyms include MMAE peptide and SGD-1010.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 13 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Auristatin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Auristatin

View every impurity, metabolite and intermediate we list for Auristatin.

Auristatin impurities

Specifications & identifiers

Chemical identifiers
Product name	Monomethylauristatin E
Catalogue No.	VQ-030258
CAS Number	474645-27-7
IUPAC name	(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide
Molecular formula	C₃₉H₆₇N₅O₇
Molecular weight	718 g/mol
Exact mass	717.504
Grade	Reference Standard
HSN code	38229090
InChIKey	DASWEROEPLKSEI-UIJRFTGLSA-N
SMILES	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
PubChem CID	11542188

Physical properties
Physical form	Solid
LogP (XLogP3)	4.1
H-bond donors / acceptors	4 / 8
TPSA	150 Å²
Synonyms	MMAE peptide, SGD-1010, MMAE (Monomethyl auristatin E), Monomethyl auristatin E (GMP), [3H]-Vedotin, Monomethyl auristatin E (MMAE), MMAE, monomethyl auristatin E, MonoMethyl auristatin E(MMAE, vedotin)

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H300+H330Fatal if swallowed or if inhaled
H300Fatal if swallowed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H330Fatal if inhaled
H335May cause respiratory irritation
H340May cause genetic defects
H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P264, P264 + P265, P270, P271, P273, P280, P284, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P308 + P316, P316, P318, P319, P320, P321, P330, P332 + P317, P337 + P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Monomethylauristatin E?

The CAS Registry Number of Monomethylauristatin E is 474645-27-7. It is also known as MMAE peptide, SGD-1010, MMAE (Monomethyl auristatin E).

What is the molecular formula and molecular weight of Monomethylauristatin E?

Monomethylauristatin E has the molecular formula C39H67N5O7 and a molecular weight of 718 g/mol.

What is Monomethylauristatin E used for?

Monomethylauristatin E is supplied as a characterised reference material related to Auristatin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Monomethylauristatin E can I order?

We supply Monomethylauristatin E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Monomethylauristatin E?

Yes. Every lot of Monomethylauristatin E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Monomethylauristatin E be shipped internationally?

Yes. Monomethylauristatin E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.