N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymeth… 1426129-50-1

Name: N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester
Brand: Vaqora Chemicals
SKU: VQ-023707

About N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester

Listed under CAS 1426129-50-1, N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester is a metabolite or degradation product of Sacubitril available from Vaqora Chemicals. The compound has the formula C20H25NO3, corresponding to a molecular weight of 327.4 g/mol. Its systematic (IUPAC) name is tert-butyl N-[(2R)-1-hydroxy-3-(4-phenylphenyl)propan-2-yl]carbamate. Alternative names: LCZ696 InteMediate and LCZ-696 Intermediate 39.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Sacubitril, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sacubitril

View every impurity, metabolite and intermediate we list for Sacubitril.

Sacubitril impurities

Specifications & identifiers

Chemical identifiers
Product name	N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester
Catalogue No.	VQ-023707
CAS Number	1426129-50-1
IUPAC name	tert-butyl N-[(2R)-1-hydroxy-3-(4-phenylphenyl)propan-2-yl]carbamate
Molecular formula	C₂₀H₂₅NO₃
Molecular weight	327.4 g/mol
Exact mass	327.1834
Grade	Reference Standard
HSN code	38229090
InChIKey	TYQICOFAZDVKMK-GOSISDBHSA-N
SMILES	CC(C)(C)OC(=O)N[C@H](CC1=CC=C(C=C1)C2=CC=CC=C2)CO
PubChem CID	71511817

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	2 / 3
TPSA	58.6 Å²
Synonyms	(R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, LCZ696 InteMediate, (R)-tert-butyl(1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, LCZ-696 Intermediate 39, (R)-tert-butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, (R)-2-(Boc-amino)-3-(4-biphenylyl)-1-propanol, (r)-2-(t-butoxycarbonylamino)-3-(biphenyl-4-yl)-propan-1-ol, (R)-t-Butyl 1-(biphenyl-4-yl)-3-hydroxypropan-2-ylcarbamate, tert-Butyl [(2R)-1-(biphenyl-4-yl)-3-hydroxypropan-2-yl]carbamate, (R)-tert-butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, (R)-tert-butyl-(1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, tert-Butyl [(R)-1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl]carbamate

Safety & hazard information (GHS)

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P273, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester?

The CAS Registry Number of N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester is 1426129-50-1. It is also known as (R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, LCZ696 InteMediate, (R)-tert-butyl(1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate.

What is the molecular formula and molecular weight of N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester?

N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester has the molecular formula C20H25NO3 and a molecular weight of 327.4 g/mol. Its IUPAC name is tert-butyl N-[(2R)-1-hydroxy-3-(4-phenylphenyl)propan-2-yl]carbamate.

What is N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester used for?

N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester is supplied as a characterised reference material related to Sacubitril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester can I order?

We supply N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester?

Yes. Every lot of N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester be shipped internationally?

Yes. We export N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.