N-Desmethyl Neratinib

Name: N-Desmethyl Neratinib
Brand: Vaqora Chemicals
SKU: VQ-023231

About N-Desmethyl Neratinib

Listed under CAS 915788-27-1, N-Desmethyl Neratinib is a metabolite or degradation product of Neratinib available from Vaqora Chemicals. Formula C29H27ClN6O3, molecular weight 543.0 g/mol. The IUPAC name is (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(methylamino)but-2-enamide. It is also known as N-Desmethyl HKI-272 or Neratinib metabolite M6.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Neratinib, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Neratinib

View every impurity, metabolite and intermediate we list for Neratinib.

Neratinib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Neratinib
Catalogue No.	VQ-023231
CAS Number	915788-27-1
IUPAC name	(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(methylamino)but-2-enamide
Molecular formula	C₂₉H₂₇ClN₆O₃
Molecular weight	543 g/mol
Exact mass	542.1833
Grade	Reference Standard
HSN code	38229090
InChIKey	PBRLDMHPDXNMBV-SOFGYWHQSA-N
SMILES	CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CNC
PubChem CID	11961295

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	3 / 8
TPSA	121 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Neratinib?

The CAS Registry Number of N-Desmethyl Neratinib is 915788-27-1. It is also known as N-Desmethyl HKI-272, Neratinib metabolite M6.

What is the molecular formula and molecular weight of N-Desmethyl Neratinib?

N-Desmethyl Neratinib has the molecular formula C29H27ClN6O3 and a molecular weight of 543 g/mol. Its IUPAC name is (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(methylamino)but-2-enamide.

What is N-Desmethyl Neratinib used for?

N-Desmethyl Neratinib is supplied as a characterised reference material related to Neratinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Neratinib can I order?

We supply N-Desmethyl Neratinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Neratinib?

Yes. Every lot of N-Desmethyl Neratinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Neratinib be shipped internationally?

Yes. We export N-Desmethyl Neratinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.