N-Desmethyl Tadalafil

Name: N-Desmethyl Tadalafil
Brand: Vaqora Chemicals
SKU: VQ-028181

About N-Desmethyl Tadalafil

N-Desmethyl Tadalafil (CAS 171596-36-4) is a metabolite or degradation product of Tadalafil offered by Vaqora Chemicals. With the molecular formula C21H17N3O4, it has a molar mass of 375.4 g/mol. It is also known as Nor-Tadalafil or (+)-Nortadalafil.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Tadalafil, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies N-Desmethyl Tadalafil in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Tadalafil

View every impurity, metabolite and intermediate we list for Tadalafil.

Tadalafil impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Tadalafil
Catalogue No.	VQ-028181
CAS Number	171596-36-4
IUPAC name	(2R,8R)-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
Molecular formula	C₂₁H₁₇N₃O₄
Molecular weight	375.4 g/mol
Exact mass	375.1219
Grade	Reference Standard
HSN code	38229090
InChIKey	XHDLVMPUSXRZOS-FOIQADDNSA-N
SMILES	C1[C@@H]2C(=O)NCC(=O)N2[C@@H](C3=C1C4=CC=CC=C4N3)C5=CC6=C(C=C5)OCO6
PubChem CID	9820973

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	2 / 4
TPSA	83.7 Å²
Synonyms	Nor-Tadalafil, (+)-Nortadalafil, Demethyl Tadalafil, Desmethyltadalafil (Nortadalafil), Tadalafil-Nor, Desmethyl Tadalafil

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Tadalafil?

The CAS Registry Number of N-Desmethyl Tadalafil is 171596-36-4. It is also known as Nor-Tadalafil, (+)-Nortadalafil, Demethyl Tadalafil.

What is the molecular formula and molecular weight of N-Desmethyl Tadalafil?

N-Desmethyl Tadalafil has the molecular formula C21H17N3O4 and a molecular weight of 375.4 g/mol. Its IUPAC name is (2R,8R)-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione.

What is N-Desmethyl Tadalafil used for?

N-Desmethyl Tadalafil is supplied as a characterised reference material related to Tadalafil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Tadalafil can I order?

We supply N-Desmethyl Tadalafil in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Tadalafil?

Yes. Every lot of N-Desmethyl Tadalafil is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Tadalafil be shipped internationally?

Yes. N-Desmethyl Tadalafil is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.