![(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide chemical structure](/media/structures/PCNIZAHOODODDG-IIBYNOLFSA-N.svg)
(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide
- CAS
- 951661-81-7
- Formula
- C22H20ClN3O4
- MW
- 425.9 g/mol
VQ-028189
Impurity reference standards
Tadalafil impurities & reference standards
Characterised Tadalafil impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
51reference materials
2isotope-labelled
COAHPLC · NMR · MS on request
![(1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid chemical structure](/media/structures/MDXJJOKTGDJRNN-RHSMWYFYSA-N.svg)
(1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
- CAS
- 406938-39-4
- Formula
- C19H16N2O4
- MW
- 336.3 g/mol
VQ-034020
![(1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide chemical structure](/media/structures/QWRJNDUNSMFZTP-CRAIPNDOSA-N.svg)
(1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
- CAS
- 951661-82-8
- Formula
- C20H19N3O3
- MW
- 349.4 g/mol
VQ-028187
![(1R,3R)-9H-Pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride chemical structure](/media/structures/ROYJOKDTCKPQHK-KQKCUOLZSA-N.svg)
(1R,3R)-9H-Pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride
- CAS
- 171752-68-4
- Formula
- C20H19ClN2O4
- MW
- 386.8 g/mol
VQ-028186
![(1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate chemical structure](/media/structures/LIPVUDSNGRJSQE-CRAIPNDOSA-N.svg)
(1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
- CAS
- 171596-41-1
- Formula
- C20H18N2O4
- MW
- 350.4 g/mol
VQ-034016
![(1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester chemical structure](/media/structures/JUKHNCNDFOAFLT-HRAATJIYSA-N.svg)
(1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester
- CAS
- 629652-44-4
- Formula
- C22H19ClN2O5
- MW
- 426.8 g/mol
VQ-034900
![(1R,3S)-Methyl1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate chemical structure](/media/structures/LIPVUDSNGRJSQE-MAUKXSAKSA-N.svg)
(1R,3S)-Methyl1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
- CAS
- 171596-44-4
- Formula
- C20H18N2O4
- MW
- 350.4 g/mol
VQ-034015
![(1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester chemical structure](/media/structures/JUKHNCNDFOAFLT-IERDGZPVSA-N.svg)
(1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester
- CAS
- 629652-40-0
- Formula
- C22H19ClN2O5
- MW
- 426.8 g/mol
VQ-023827
![(1S,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate chemical structure](/media/structures/LIPVUDSNGRJSQE-QAPCUYQASA-N.svg)
(1S,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
- CAS
- 171596-42-2
- Formula
- C20H18N2O4
- MW
- 350.4 g/mol
VQ-023826
![(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester chemical structure](/media/structures/JUKHNCNDFOAFLT-KKSFZXQISA-N.svg)
(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester
- CAS
- 629652-42-2
- Formula
- C22H19ClN2O5
- MW
- 426.8 g/mol
VQ-023830
![(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester chemical structure](/media/structures/LIPVUDSNGRJSQE-YJBOKZPZSA-N.svg)
(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester
- CAS
- 171596-43-3
- Formula
- C20H18N2O4
- MW
- 350.4 g/mol
VQ-023825
![(3R)-3-[[2-(1,3-Benzodioxol-5-ylcarbonyl)-1H-indol-3-yl]methyl]-1-methyl-2,5-piperazinedione chemical structure](/media/structures/SXWTYPIIBMLMNG-UHFFFAOYSA-N.svg)
(3R)-3-[[2-(1,3-Benzodioxol-5-ylcarbonyl)-1H-indol-3-yl]methyl]-1-methyl-2,5-piperazinedione
- CAS
- 1220393-12-3
- Formula
- C22H19N3O5
- MW
- 405.4 g/mol
VQ-042340
![(6S,12AS)-6-(3,4-Dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione chemical structure](/media/structures/HZSPPSAESSMSNY-YWZLYKJASA-N.svg)
(6S,12AS)-6-(3,4-Dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
- CAS
- 2520114-84-3
- Formula
- C21H19N3O4
- MW
- 377.4 g/mol
VQ-044192
5-(Aminomethyl)-2-methylpyrimidin-4-amine hydrochloride
- CAS
- 1195-07-9
- Formula
- C6H11ClN4
- MW
- 174.63 g/mol
VQ-042488
FAQs — Tadalafil impurities
Which Tadalafil impurities do you supply?
We list 51 Tadalafil-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Tadalafil impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Tadalafil impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Tadalafil impurity standards
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