N-Methyl Paroxetine

Name: N-Methyl Paroxetine
Brand: Vaqora Chemicals
SKU: VQ-023469

About N-Methyl Paroxetine

Listed under CAS 110429-36-2, N-Methyl Paroxetine is an impurity of Paroxetine available from Vaqora Chemicals. Its molecular formula is C20H22FNO3 and its molecular weight is 343.4 g/mol. Systematically, it is named (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-1-methylpiperidine. It is also known as (3S,4R)-N-Methylparoxetine or trans-(-)-N-methylparoxetine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Paroxetine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Methyl Paroxetine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Paroxetine

View every impurity, metabolite and intermediate we list for Paroxetine.

Paroxetine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Methyl Paroxetine
Catalogue No.	VQ-023469
CAS Number	110429-36-2
IUPAC name	(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-1-methylpiperidine
Molecular formula	C₂₀H₂₂FNO₃
Molecular weight	343.4 g/mol
Exact mass	343.1584
Grade	Reference Standard
HSN code	38229090
InChIKey	MOJZPKOBKCXNKG-YJBOKZPZSA-N
SMILES	CN1CC[C@H]([C@@H](C1)COC2=CC3=C(C=C2)OCO3)C4=CC=C(C=C4)F
PubChem CID	10947895

Physical properties
Physical form	Solid
LogP (XLogP3)	4
H-bond donors / acceptors	0 / 5
TPSA	30.9 Å²
Synonyms	(3S,4R)-N-Methylparoxetine, trans-(-)-N-methylparoxetine, (-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-methylpiperidine, (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine, Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl-, (3S,4R)-, (3S,4R)-(-)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine, (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine, Trans-(-)-3-((1,3-Benzodioxol-5-yloxyl)-Methyl)-4-(4-FluoroPhenyl)-1-methyl Piperidine, Trans-(-)-3-[(1,3-Benzodioxol-5-yloxyl)-Methyl]-4-(4-FluoroPhenyl)-1-methyl Piperidine, (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

Safety & hazard information (GHS)

Toxic

Environmental hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P264, P270, P273, P301 + P316, P321, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Methyl Paroxetine?

The CAS Registry Number of N-Methyl Paroxetine is 110429-36-2. It is also known as (3S,4R)-N-Methylparoxetine, trans-(-)-N-methylparoxetine, (-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-methylpiperidine.

What is the molecular formula and molecular weight of N-Methyl Paroxetine?

N-Methyl Paroxetine has the molecular formula C20H22FNO3 and a molecular weight of 343.4 g/mol. Its IUPAC name is (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-1-methylpiperidine.

What is N-Methyl Paroxetine used for?

N-Methyl Paroxetine is supplied as a characterised reference material related to Paroxetine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Methyl Paroxetine can I order?

We supply N-Methyl Paroxetine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Methyl Paroxetine?

Yes. Every lot of N-Methyl Paroxetine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Methyl Paroxetine be shipped internationally?

Yes. N-Methyl Paroxetine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.