Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophen… 105812-81-5

Name: Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine
Brand: Vaqora Chemicals
SKU: VQ-023472

About Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine

Listed under CAS 105812-81-5, Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine is an impurity of Paroxetine available from Vaqora Chemicals. Its molecular formula is C13H18FNO and its molecular weight is 223.29 g/mol. Its systematic (IUPAC) name is [(3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl]methanol. Common synonyms include (3S,4R)-N-Methyl Paroxol and Paroxol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Paroxetine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Paroxetine

View every impurity, metabolite and intermediate we list for Paroxetine.

Paroxetine impurities

Specifications & identifiers

Chemical identifiers
Product name	Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine
Catalogue No.	VQ-023472
CAS Number	105812-81-5
IUPAC name	[(3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl]methanol
Molecular formula	C₁₃H₁₈FNO
Molecular weight	223.29 g/mol
Exact mass	223.1372
Grade	Reference Standard
HSN code	38229090
InChIKey	CXRHUYYZISIIMT-AAEUAGOBSA-N
SMILES	CN1CC[C@H]([C@@H](C1)CO)C2=CC=C(C=C2)F
PubChem CID	2734218

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	1 / 3
TPSA	23.5 Å²
Synonyms	(3S,4R)-N-Methyl Paroxol, (3S,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol, (-)-trans-4-(4'-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine, (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, Paroxol, ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methanol, 3-Piperidinemethanol, 4-(4-fluorophenyl)-1-methyl-, (3S,4R)-, (+/-)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine, 4-(4'-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, (-)-trans-, 4-(4-Fluorophenyl)-3-(hydroxymethyl)-1-methylpiperidine, (+/-)-trans-, rac-trans Paroxol, (-)-Paroxol

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Environmental hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H318Causes serious eye damage
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P264, P264 + P265, P270, P273, P280, P301 + P317, P305 + P354 + P338, P317, P330, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine?

The CAS Registry Number of Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine is 105812-81-5. It is also known as (3S,4R)-N-Methyl Paroxol, (3S,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol, (-)-trans-4-(4'-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine.

What is the molecular formula and molecular weight of Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine?

Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine has the molecular formula C13H18FNO and a molecular weight of 223.29 g/mol. Its IUPAC name is [(3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl]methanol.

What is Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine used for?

Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine is supplied as a characterised reference material related to Paroxetine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine can I order?

We supply Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine?

Yes. Every lot of Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine be shipped internationally?

Yes. Trans-(-)-Paroxol / (-)-trans-4-(4-Fluorophenyl)-N-methyl-3-hydroxymethylpiperidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.