Naloxone EP Impurity E

Name: Naloxone EP Impurity E
Brand: Vaqora Chemicals
SKU: VQ-043238

About Naloxone EP Impurity E

Naloxone EP Impurity E (CAS 211738-08-8) is a pharmacopeial impurity of Naloxon offered by Vaqora Chemicals. The compound has the formula C38H40N2O8, corresponding to a molecular weight of 652.7 g/mol. Alternative names: Naloxone Hydrochloride EP Impurity E and Naloxone Hydrochloride - Impurity E.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 6 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Naloxon, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Naloxon

View every impurity, metabolite and intermediate we list for Naloxon.

Naloxon impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Naloxone EP Impurity E
Catalogue No.	VQ-043238
CAS Number	211738-08-8
IUPAC name	(4R,4aS,7aR,12bS)-10-[(4R,4aS,7aR,12bS)-4a,9-dihydroxy-7-oxo-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-10-yl]-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formula	C₃₈H₄₀N₂O₈
Molecular weight	652.7 g/mol
Exact mass	652.2785
Grade	Reference Standard
HSN code	38229090
InChIKey	VZXBORUALALXQH-ZQUSMLRHSA-N
SMILES	C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=CC(=C(C(=C35)O4)O)C6=C(C7=C8C(=C6)C[C@@H]9[C@]1([C@]8(CCN9CC=C)[C@@H](O7)C(=O)CC1)O)O)O
PubChem CID	129011921

Physical properties
Physical form	Solid
LogP (XLogP3)	2.6
H-bond donors / acceptors	4 / 10
TPSA	140 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301 + P317, P302 + P352, P304 + P340, P317, P318, P321, P330, P333 + P317, P342 + P316, P362 + P364, P403, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Naloxone EP Impurity E?

The CAS Registry Number of Naloxone EP Impurity E is 211738-08-8. It is also known as Naloxone Hydrochloride EP Impurity E, Naloxone Hydrochloride - Impurity E, 2,2'-Bisnaloxone.

What is the molecular formula and molecular weight of Naloxone EP Impurity E?

Naloxone EP Impurity E has the molecular formula C38H40N2O8 and a molecular weight of 652.7 g/mol.

What is Naloxone EP Impurity E used for?

Naloxone EP Impurity E is supplied as a characterised reference material related to Naloxon. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Naloxone EP Impurity E can I order?

We supply Naloxone EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Naloxone EP Impurity E?

Yes. Every lot of Naloxone EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Naloxone EP Impurity E be shipped internationally?

Yes. Naloxone EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.