Naloxone Hydrochloride

Name: Naloxone Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-007598

About Naloxone Hydrochloride

Naloxone Hydrochloride is a high-purity reference standard of Naloxone carrying the CAS registry number 357-08-4. With the molecular formula C19H22ClNO4, it has a molar mass of 363.8 g/mol. It is also known as (-)-Naloxone hydrochloride or Naloxone HCl.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Naloxone standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Naloxone Hydrochloride in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Naloxone

View every impurity, metabolite and intermediate we list for Naloxone.

Naloxone impurities

Specifications & identifiers

Chemical identifiers
Product name	Naloxone Hydrochloride
Catalogue No.	VQ-007598
CAS Number	357-08-4
Other CAS	465-65-6, 51481-60-8
IUPAC name	(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
Molecular formula	C₁₉H₂₂ClNO₄
Molecular weight	363.8 g/mol
Exact mass	363.1237
Grade	Reference Standard
HSN code	38229090
InChIKey	RGPDIGOSVORSAK-STHHAXOLSA-N
SMILES	C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
PubChem CID	5464092

Physical properties
Physical form	Solid
H-bond donors / acceptors	3 / 5
TPSA	70 Å²
Synonyms	(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one Hydrochloride, (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride, N-Allyldihydro-14-hydroxynormorphinone hydrochloride, (-)-Naloxone hydrochloride, Naloxone HCl, NIH 7890, Anhydrous naloxone hydrochloride, Naloxone hydrochloride anhydrous, Naloxoni hydrochloridum anhydrous, Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5alpha)-, Narcan neonatal, Nalxone Hydrochloride

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P270, P280, P301 + P317, P302 + P352, P305 + P351 + P338, P305 + P354 + P338, P317, P321, P330, P332 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Naloxone Hydrochloride?

The CAS Registry Number of Naloxone Hydrochloride is 357-08-4. It is also known as (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one Hydrochloride, (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride, N-Allyldihydro-14-hydroxynormorphinone hydrochloride.

What is the molecular formula and molecular weight of Naloxone Hydrochloride?

Naloxone Hydrochloride has the molecular formula C19H22ClNO4 and a molecular weight of 363.8 g/mol.

What is Naloxone Hydrochloride used for?

Naloxone Hydrochloride is supplied as a characterised reference material related to Naloxone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Naloxone Hydrochloride can I order?

We supply Naloxone Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Naloxone Hydrochloride?

Yes. Every lot of Naloxone Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Naloxone Hydrochloride be shipped internationally?

Yes. Naloxone Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.