Nintedanib Impurity E

Name: Nintedanib Impurity E
Brand: Vaqora Chemicals
SKU: VQ-005382

About Nintedanib Impurity E

Nintedanib Impurity E is an impurity of Nintedanib carrying the CAS registry number 2380229-45-6. Formula C33H35N5O5, molecular weight 581.7 g/mol. Common synonyms include N-Acetyl Nintedanib and Nintedanib N-Acetyl Impurity.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Nintedanib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	Nintedanib Impurity E
Catalogue No.	VQ-005382
CAS Number	2380229-45-6
IUPAC name	methyl 1-acetyl-2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]indole-6-carboxylate
Molecular formula	C₃₃H₃₅N₅O₅
Molecular weight	581.7 g/mol
Exact mass	581.2638
Grade	Reference Standard
HSN code	38229090
InChIKey	CFLKIPWPSHALCH-UHFFFAOYSA-N
SMILES	CC(=O)N1C2=C(C=CC(=C2)C(=O)OC)C(=C1O)C(=NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(CC4)C)C5=CC=CC=C5
PubChem CID	137095372

Physical properties
Physical form	Solid
LogP (XLogP3)	4.7
H-bond donors / acceptors	1 / 8
TPSA	108 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nintedanib Impurity E?

The CAS Registry Number of Nintedanib Impurity E is 2380229-45-6. It is also known as N-Acetyl Nintedanib, Nintedanib N-Acetyl Impurity, Intedanib Impurity E.

What is the molecular formula and molecular weight of Nintedanib Impurity E?

Nintedanib Impurity E has the molecular formula C33H35N5O5 and a molecular weight of 581.7 g/mol. Its IUPAC name is methyl 1-acetyl-2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]indole-6-carboxylate.

What is Nintedanib Impurity E used for?

Nintedanib Impurity E is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nintedanib Impurity E can I order?

We supply Nintedanib Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nintedanib Impurity E?

Yes. Every lot of Nintedanib Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nintedanib Impurity E be shipped internationally?

Yes. Nintedanib Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.