Nintedanib Nitroso Impurity 2 (Stage-I)

Name: Nintedanib Nitroso Impurity 2 (Stage-I)
Brand: Vaqora Chemicals
SKU: VQ-007009

About Nintedanib Nitroso Impurity 2 (Stage-I)

Listed under CAS 1277571-69-3, Nintedanib Nitroso Impurity 2 (Stage-I) is a nitrosamine impurity of Nintedanib available from Vaqora Chemicals with a typical assay of 97%. With the molecular formula C18H26N4O5, it has a molar mass of 378.4 g/mol. Its systematic (IUPAC) name is tert-butyl 4-[2-(N-methyl-4-nitroanilino)-2-oxoethyl]piperazine-1-carboxylate. Alternative names: Nintedanib Impurity 88.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Nintedanib Nitroso Impurity 2 (Stage-I) in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	Nintedanib Nitroso Impurity 2 (Stage-I)
Catalogue No.	VQ-007009
CAS Number	1277571-69-3
IUPAC name	tert-butyl 4-[2-(N-methyl-4-nitroanilino)-2-oxoethyl]piperazine-1-carboxylate
Molecular formula	C₁₈H₂₆N₄O₅
Molecular weight	378.4 g/mol
Exact mass	378.1903
Grade	Reference Standard
Purity / assay	97%
HSN code	38229090
InChIKey	AKEPYQCUNJBUFH-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)[N+](=O)[O-]
PubChem CID	55591601

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	0 / 6
TPSA	98.9 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nintedanib Nitroso Impurity 2 (Stage-I)?

The CAS Registry Number of Nintedanib Nitroso Impurity 2 (Stage-I) is 1277571-69-3. It is also known as tert-butyl 4-(2-(methyl(4-nitrophenyl)amino)-2-oxoethyl)piperazine-1-carboxylate, Nintedanib Impurity 88.

What is the molecular formula and molecular weight of Nintedanib Nitroso Impurity 2 (Stage-I)?

Nintedanib Nitroso Impurity 2 (Stage-I) has the molecular formula C18H26N4O5 and a molecular weight of 378.4 g/mol. Its IUPAC name is tert-butyl 4-[2-(N-methyl-4-nitroanilino)-2-oxoethyl]piperazine-1-carboxylate.

What is Nintedanib Nitroso Impurity 2 (Stage-I) used for?

Nintedanib Nitroso Impurity 2 (Stage-I) is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nintedanib Nitroso Impurity 2 (Stage-I) can I order?

We supply Nintedanib Nitroso Impurity 2 (Stage-I) in Reference Standard (97%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nintedanib Nitroso Impurity 2 (Stage-I)?

Yes. Every lot of Nintedanib Nitroso Impurity 2 (Stage-I) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nintedanib Nitroso Impurity 2 (Stage-I) be shipped internationally?

Yes. We export Nintedanib Nitroso Impurity 2 (Stage-I) worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.