Nintedanib 4-Nitrophenyl 2-(4-Nitroso)

Name: Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
Brand: Vaqora Chemicals
SKU: VQ-007008

About Nintedanib 4-Nitrophenyl 2-(4-Nitroso)

Listed under CAS 2490403-92-2, Nintedanib 4-Nitrophenyl 2-(4-Nitroso) is a nitrosamine impurity of Nintedanib available from Vaqora Chemicals, specified at 98% purity. Its molecular formula is C13H17N5O4 and its molecular weight is 307.31 g/mol. Systematically, it is named N-methyl-N-(4-nitrophenyl)-2-(4-nitrosopiperazin-1-yl)acetamide. It is also known as N-methyl-N-(4-nitrophenyl)-4-nitroso.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Nintedanib 4-Nitrophenyl 2-(4-Nitroso) in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
Catalogue No.	VQ-007008
CAS Number	2490403-92-2
IUPAC name	N-methyl-N-(4-nitrophenyl)-2-(4-nitrosopiperazin-1-yl)acetamide
Molecular formula	C₁₃H₁₇N₅O₄
Molecular weight	307.31 g/mol
Exact mass	307.1281
Grade	Reference Standard
Purity / assay	98%
HSN code	38229090
InChIKey	BXTDJRYUGBIVDM-UHFFFAOYSA-N
SMILES	CN(C1=CC=C(C=C1)[N+](=O)[O-])C(=O)CN2CCN(CC2)N=O
PubChem CID	155820971

Physical properties
Physical form	Solid
LogP (XLogP3)	0.9
H-bond donors / acceptors	0 / 7
TPSA	102 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H351Suspected of causing cancer

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nintedanib 4-Nitrophenyl 2-(4-Nitroso)?

The CAS Registry Number of Nintedanib 4-Nitrophenyl 2-(4-Nitroso) is 2490403-92-2. It is also known as N-Methyl-N-(4-nitrophenyl)-4-nitroso-1-piperazineacetamide, N-methyl-N-(4-nitrophenyl)-4-nitroso.

What is the molecular formula and molecular weight of Nintedanib 4-Nitrophenyl 2-(4-Nitroso)?

Nintedanib 4-Nitrophenyl 2-(4-Nitroso) has the molecular formula C13H17N5O4 and a molecular weight of 307.31 g/mol. Its IUPAC name is N-methyl-N-(4-nitrophenyl)-2-(4-nitrosopiperazin-1-yl)acetamide.

What is Nintedanib 4-Nitrophenyl 2-(4-Nitroso) used for?

Nintedanib 4-Nitrophenyl 2-(4-Nitroso) is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nintedanib 4-Nitrophenyl 2-(4-Nitroso) can I order?

We supply Nintedanib 4-Nitrophenyl 2-(4-Nitroso) in Reference Standard (98%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nintedanib 4-Nitrophenyl 2-(4-Nitroso)?

Yes. Every lot of Nintedanib 4-Nitrophenyl 2-(4-Nitroso) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nintedanib 4-Nitrophenyl 2-(4-Nitroso) be shipped internationally?

Yes. Nintedanib 4-Nitrophenyl 2-(4-Nitroso) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.