(R)-Sitagliptin N-Boc-Acid Impurity

Name: (R)-Sitagliptin N-Boc-Acid Impurity
Brand: Vaqora Chemicals
SKU: VQ-004273

About (R)-Sitagliptin N-Boc-Acid Impurity

Listed under CAS 486460-00-8, (R)-Sitagliptin N-Boc-Acid Impurity is an impurity of Sitagliptin available from Vaqora Chemicals. Formula C15H18F3NO4, molecular weight 333.3 g/mol. Its systematic (IUPAC) name is (3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-(2,4,5-trifluorophenyl)butanoic acid. It is also known as Sitagliptin Impurity 58.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Sitagliptin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer (R)-Sitagliptin N-Boc-Acid Impurity in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	(R)-Sitagliptin N-Boc-Acid Impurity
Catalogue No.	VQ-004273
CAS Number	486460-00-8
IUPAC name	(3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-(2,4,5-trifluorophenyl)butanoic acid
Molecular formula	C₁₅H₁₈F₃NO₄
Molecular weight	333.3 g/mol
Exact mass	333.1188
Grade	Reference Standard
HSN code	38229090
InChIKey	TUAXCHGULMWHIO-SECBINFHSA-N
SMILES	CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1F)F)F)CC(=O)O
PubChem CID	7146288

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	2 / 7
TPSA	75.6 Å²
Synonyms	(βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid, (3R)-3-[(1,1-Dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic Acid, (3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic Acid, (3R)-3-[N-(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic Acid, (R)-3-(((tert-Butoxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butyric Acid, (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid, (R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid, N-Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid, Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic Acid, Sitagliptin Impurity 58, (3R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 486460-00-8

(3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid, 98%

CAS: 486460-00-8
Formula: C₁₅H₁₈F₃NO₄
MW: 333.3 g/mol

VQ-002164

Frequently asked questions

What is the CAS number of (R)-Sitagliptin N-Boc-Acid Impurity?

The CAS Registry Number of (R)-Sitagliptin N-Boc-Acid Impurity is 486460-00-8. It is also known as (βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid, (3R)-3-[(1,1-Dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic Acid, (3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic Acid.

What is the molecular formula and molecular weight of (R)-Sitagliptin N-Boc-Acid Impurity?

(R)-Sitagliptin N-Boc-Acid Impurity has the molecular formula C15H18F3NO4 and a molecular weight of 333.3 g/mol. Its IUPAC name is (3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-(2,4,5-trifluorophenyl)butanoic acid.

What is (R)-Sitagliptin N-Boc-Acid Impurity used for?

(R)-Sitagliptin N-Boc-Acid Impurity is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (R)-Sitagliptin N-Boc-Acid Impurity can I order?

We supply (R)-Sitagliptin N-Boc-Acid Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (R)-Sitagliptin N-Boc-Acid Impurity?

Yes. Every lot of (R)-Sitagliptin N-Boc-Acid Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (R)-Sitagliptin N-Boc-Acid Impurity be shipped internationally?

Yes. (R)-Sitagliptin N-Boc-Acid Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.