Sitagliptin

Name: Sitagliptin
Brand: Vaqora Chemicals
SKU: VQ-004146

About Sitagliptin

Sitagliptin (CAS 486460-32-6) is a metabolic / hormonal API offered by Vaqora Chemicals in IP/BP/USP grade at a purity of 99%. With the molecular formula C16H15F6N5O, it has a molar mass of 407.31 g/mol. It is also known as sitagliptine or LEZ-763.

The material typically appears as a white crystalline powder. Store in a tightly closed container in a cool, dry and well-ventilated place. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This API belongs to our antidiabetic, hormone and metabolic APIs portfolio and is supplied to IP/BP/USP specifications for formulators, contract manufacturers and generic drug developers. Our customers for this product work in pharmaceutical manufacturing.

Vaqora Chemicals supplies Sitagliptin in 1 kg, 5 kg and 25 kg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Pharmaceutical synthesis
Pharmaceutical formulation

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Sitagliptin
Catalogue No.	VQ-004146
CAS Number	486460-32-6
IUPAC name	(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Molecular formula	C₁₆H₁₅F₆N₅O
Molecular weight	407.31 g/mol
Exact mass	407.1181
Grade	IP/BP/USP
Purity / assay	99%
HSN code	2933
InChIKey	MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N
PubChem CID	4369359

Physical properties
Physical form	Powder
Appearance	White crystalline powder
LogP (XLogP3)	0.7
H-bond donors / acceptors	1 / 10
TPSA	77 Å²
Synonyms	sitagliptine, LEZ-763, Sitagliptin (Metformin,MK-0431), LEZ 763, Sitagliptin (13), SitagliptinMK0431, Sitagliptin, MK0431, Sitagliptin (USAN/INN), EX-A2816, WHO 8692, Sitagliptin 100 microg/mL in Acetonitrile

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H318Causes serious eye damage
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P264, P264 + P265, P270, P280, P301 + P317, P305 + P354 + P338, P317, P319, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 486460-32-6

Reference Standard

Sitagliptin WS

CAS: 486460-32-6
Formula: C₁₆H₁₅F₆N₅O
MW: 407.31 g/mol

In stock

Frequently asked questions

What is the CAS number of Sitagliptin?

The CAS Registry Number of Sitagliptin is 486460-32-6. It is also known as sitagliptine, LEZ-763, Sitagliptin (Metformin,MK-0431).

What is the molecular formula and molecular weight of Sitagliptin?

Sitagliptin has the molecular formula C16H15F6N5O and a molecular weight of 407.31 g/mol. Its IUPAC name is (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one.

What is Sitagliptin used for?

Sitagliptin is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sitagliptin can I order?

We supply Sitagliptin in IP/BP/USP (99%) grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sitagliptin?

Yes. Every lot of Sitagliptin is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sitagliptin be shipped internationally?

Yes. Sitagliptin is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.