Rofecoxib

Name: Rofecoxib
Brand: Vaqora Chemicals
SKU: VQ-041981

About Rofecoxib

Rofecoxib is a high-purity reference standard of Rofecoxib carrying the CAS registry number 162011-90-7. Formula C17H14O4S, molecular weight 314.4 g/mol. The IUPAC name is 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one. It is also known as MK 966 or MK-966.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

Laboratories use this Rofecoxib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Rofecoxib in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Rofecoxib

View every impurity, metabolite and intermediate we list for Rofecoxib.

Rofecoxib impurities

Specifications & identifiers

Chemical identifiers
Product name	Rofecoxib
Catalogue No.	VQ-041981
CAS Number	162011-90-7
IUPAC name	3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one
Molecular formula	C₁₇H₁₄O₄S
Molecular weight	314.4 g/mol
Exact mass	314.0613
Grade	Reference Standard
HSN code	38229090
InChIKey	RZJQGNCSTQAWON-UHFFFAOYSA-N
SMILES	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3
PubChem CID	5090

Physical properties
Physical form	Solid
LogP (XLogP3)	2.3
H-bond donors / acceptors	0 / 4
TPSA	68.8 Å²
Synonyms	4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one, MK 966, MK-966, 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one, Vioxx Dolor, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone, TRM-201, 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone, 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one, 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone, 4-(4'-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Rofecoxib?

The CAS Registry Number of Rofecoxib is 162011-90-7. It is also known as 4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one, MK 966, MK-966.

What is the molecular formula and molecular weight of Rofecoxib?

Rofecoxib has the molecular formula C17H14O4S and a molecular weight of 314.4 g/mol. Its IUPAC name is 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one.

What is Rofecoxib used for?

Rofecoxib is supplied as a characterised reference material related to Rofecoxib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Rofecoxib can I order?

We supply Rofecoxib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Rofecoxib?

Yes. Every lot of Rofecoxib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Rofecoxib be shipped internationally?

Yes. Rofecoxib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.