Rolapitant

Name: Rolapitant
Brand: Vaqora Chemicals
SKU: VQ-041988

About Rolapitant

Rolapitant is a high-purity reference standard of Rolapitant carrying the CAS registry number 552292-08-7. With the molecular formula C25H26F6N2O2, it has a molar mass of 500.5 g/mol. Systematically, it is named (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one. It is also known as Rolapitant free base or Rolapitant(sch619734).

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Rolapitant, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Rolapitant

View every impurity, metabolite and intermediate we list for Rolapitant.

Rolapitant impurities

Specifications & identifiers

Chemical identifiers
Product name	Rolapitant
Catalogue No.	VQ-041988
CAS Number	552292-08-7
IUPAC name	(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one
Molecular formula	C₂₅H₂₆F₆N₂O₂
Molecular weight	500.5 g/mol
Exact mass	500.1898
Grade	Reference Standard
HSN code	38229090
InChIKey	FIVSJYGQAIEMOC-ZGNKEGEESA-N
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4
PubChem CID	10311306

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	2 / 9
TPSA	50.4 Å²

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Rolapitant?

The CAS Registry Number of Rolapitant is 552292-08-7. It is also known as Rolapitant free base, Rolapitant(sch619734), EX-A1288.

What is the molecular formula and molecular weight of Rolapitant?

Rolapitant has the molecular formula C25H26F6N2O2 and a molecular weight of 500.5 g/mol. Its IUPAC name is (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one.

What is Rolapitant used for?

Rolapitant is supplied as a characterised reference material related to Rolapitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Rolapitant can I order?

We supply Rolapitant in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Rolapitant?

Yes. Every lot of Rolapitant is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Rolapitant be shipped internationally?

Yes. Rolapitant is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.