(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3… 2413212-07-2

Name: (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Brand: Vaqora Chemicals
SKU: VQ-028797

About (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine is an impurity of Afatinib carrying the CAS registry number 2413212-07-2. Formula C18H17FN4O2, molecular weight 340.4 g/mol. Its systematic (IUPAC) name is 4-N-(4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.	VQ-028797
CAS Number	2413212-07-2
IUPAC name	4-N-(4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine
Molecular formula	C₁₈H₁₇FN₄O₂
Molecular weight	340.4 g/mol
Exact mass	340.1336
Grade	Reference Standard
HSN code	38229090
InChIKey	DCBBEFYNODKZDK-ZDUSSCGKSA-N
SMILES	C1COC[C@H]1OC2=C(C=C3C(=C2)N=CN=C3NC4=CC=C(C=C4)F)N
PubChem CID	125342095

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	2 / 7
TPSA	82.3 Å²
Synonyms	Deschloro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib, 4,6-Quinazolinediamine, N4-(4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-, N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine, (S)-, N4-(4-fluorophenyl)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazoline-4,6-diamine, N4-(4-Fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine?

The CAS Registry Number of (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine is 2413212-07-2. It is also known as Deschloro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib, 4,6-Quinazolinediamine, N4-(4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-, N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine, (S)-.

What is the molecular formula and molecular weight of (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine?

(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine has the molecular formula C18H17FN4O2 and a molecular weight of 340.4 g/mol. Its IUPAC name is 4-N-(4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine.

What is (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine used for?

(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine can I order?

We supply (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine?

Yes. Every lot of (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine be shipped internationally?

Yes. We export (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.