Afatinib-d6

Name: Afatinib-d6
Brand: Vaqora Chemicals
SKU: VQ-024160

About Afatinib-d6

Afatinib-d6 (CAS 1313874-96-2) is a stable isotope labelled analogue related to Afatinib offered by Vaqora Chemicals. The compound has the formula C24H25ClFN5O3, corresponding to a molecular weight of 492.0 g/mol.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Afatinib and related analytes in bioanalytical, pharmacokinetic and impurity studies. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Afatinib-d6 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Afatinib-d6
Catalogue No.	VQ-024160
CAS Number	1313874-96-2
IUPAC name	(E)-4-[bis(trideuteriomethyl)amino]-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide
Molecular formula	C₂₄H₂₅ClFN₅O₃
Molecular weight	492 g/mol
Exact mass	491.2007
Grade	Reference Standard
HSN code	38229090
InChIKey	ULXXDDBFHOBEHA-VCXSEIMGSA-N
SMILES	[2H]C([2H])([2H])N(C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4)C([2H])([2H])[2H]
PubChem CID	53254174

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	2 / 8
TPSA	88.6 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib-d6?

The CAS Registry Number of Afatinib-d6 is 1313874-96-2.

What is the molecular formula and molecular weight of Afatinib-d6?

Afatinib-d6 has the molecular formula C24H25ClFN5O3 and a molecular weight of 492 g/mol. Its IUPAC name is (E)-4-[bis(trideuteriomethyl)amino]-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide.

What is Afatinib-d6 used for?

Afatinib-d6 is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib-d6 can I order?

We supply Afatinib-d6 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib-d6?

Yes. Every lot of Afatinib-d6 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib-d6 be shipped internationally?

Yes. We export Afatinib-d6 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.