Tolcapone

Name: Tolcapone
Brand: Vaqora Chemicals
SKU: VQ-028431

About Tolcapone

Listed under CAS 134308-13-7, Tolcapone is a high-purity reference standard of Tolcapone available from Vaqora Chemicals. With the molecular formula C14H11NO5, it has a molar mass of 273.24 g/mol. Its systematic (IUPAC) name is (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone. Common synonyms include 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone and 5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Tolcapone standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Tolcapone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Tolcapone

View every impurity, metabolite and intermediate we list for Tolcapone.

Tolcapone impurities

Specifications & identifiers

Chemical identifiers
Product name	Tolcapone
Catalogue No.	VQ-028431
CAS Number	134308-13-7
IUPAC name	(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
Molecular formula	C₁₄H₁₁NO₅
Molecular weight	273.24 g/mol
Exact mass	273.0637
Grade	Reference Standard
HSN code	38229090
InChIKey	MIQPIUSUKVNLNT-UHFFFAOYSA-N
SMILES	CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
PubChem CID	4659569

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	2 / 5
TPSA	103 Å²
Synonyms	3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone, (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone, Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-, 5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol, 3,4-dihydroxy-5-nitro-4'-methylbenzophenone, 4'-methyl-3,4-dihydroxy-5-nitrobenzophenone, 5-((4-methylphenyl)carbonyl)-3-nitrobenzene-1,2-diol, Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-, (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone, 3,4-dihydroxy-4 inverted exclamation mark -methyl-5-nitrobenzophenone, Talcapone

Safety & hazard information (GHS)

Environmental hazard

Signal word: Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tolcapone?

The CAS Registry Number of Tolcapone is 134308-13-7. It is also known as 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone, (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone, Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-.

What is the molecular formula and molecular weight of Tolcapone?

Tolcapone has the molecular formula C14H11NO5 and a molecular weight of 273.24 g/mol. Its IUPAC name is (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone.

What is Tolcapone used for?

Tolcapone is supplied as a characterised reference material related to Tolcapone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tolcapone can I order?

We supply Tolcapone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tolcapone?

Yes. Every lot of Tolcapone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tolcapone be shipped internationally?

Yes. Tolcapone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.