Trametinib Dimethyl Sulfoxide

Name: Trametinib Dimethyl Sulfoxide
Brand: Vaqora Chemicals
SKU: VQ-023924

About Trametinib Dimethyl Sulfoxide

Trametinib Dimethyl Sulfoxide (CAS 1187431-43-1) is a metabolite or degradation product of Trametinib offered by Vaqora Chemicals. With the molecular formula C28H29FIN5O5S, it has a molar mass of 693.5 g/mol. Alternative names: Trametinib DMSO and Trametinib DMSO solvate.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Trametinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Trametinib

View every impurity, metabolite and intermediate we list for Trametinib.

Trametinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Trametinib Dimethyl Sulfoxide
Catalogue No.	VQ-023924
CAS Number	1187431-43-1
IUPAC name	N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane
Molecular formula	C₂₈H₂₉FIN₅O₅S
Molecular weight	693.5 g/mol
Exact mass	693.0918
Grade	Reference Standard
HSN code	38229090
InChIKey	OQUFJVRYDFIQBW-UHFFFAOYSA-N
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C
PubChem CID	50992434

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 8
TPSA	138 Å²
Synonyms	Trametinib DMSO, Trametinib DMSO solvate, Trametinib (DMSO solvate), GSK1120212 (DMSO solvate), JTP-74057 (DMSO solvate), EX-A5800, Trametinib dimethyl sulfoxide (JAN/USAN), Trametinib DMSO solvate (GSK1120212B)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H317May cause an allergic skin reaction
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P264, P270, P272, P273, P280, P302 + P352, P318, P319, P321, P333 + P317, P362 + P364, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trametinib Dimethyl Sulfoxide?

The CAS Registry Number of Trametinib Dimethyl Sulfoxide is 1187431-43-1. It is also known as Trametinib DMSO, Trametinib DMSO solvate, Trametinib (DMSO solvate).

What is the molecular formula and molecular weight of Trametinib Dimethyl Sulfoxide?

Trametinib Dimethyl Sulfoxide has the molecular formula C28H29FIN5O5S and a molecular weight of 693.5 g/mol.

What is Trametinib Dimethyl Sulfoxide used for?

Trametinib Dimethyl Sulfoxide is supplied as a characterised reference material related to Trametinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trametinib Dimethyl Sulfoxide can I order?

We supply Trametinib Dimethyl Sulfoxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trametinib Dimethyl Sulfoxide?

Yes. Every lot of Trametinib Dimethyl Sulfoxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trametinib Dimethyl Sulfoxide be shipped internationally?

Yes. Trametinib Dimethyl Sulfoxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.