(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
- CAS
- 2517869-16-6
- Formula
- C9H10ClF2N
- MW
- 205.63 g/mol
VQ-042519
Impurity reference standards
Trametinib impurities & reference standards
Characterised Trametinib impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
27reference materials
1nitrosamine impurities
1isotope-labelled
COAHPLC · NMR · MS on request
Parent API: Trametinib
871700-17-3 · C26H23FIN5O4
(1R,2S)-2-(4-Chloro-3-fluorophenyl)cyclopropan-1-amine
- CAS
- 2166301-04-6
- Formula
- C9H9ClFN
- MW
- 185.62 g/mol
VQ-042545
(E)-N'-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide
- CAS
- 871700-30-0
- Formula
- C16H16FIN4O2
- MW
- 442.23 g/mol
VQ-028473
![1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione chemical structure](/media/structures/KYXOFPAKDRWYQM-UHFFFAOYSA-N.svg)
1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
- CAS
- 1620017-29-9
- Formula
- C24H21FIN5O4
- MW
- 589.4 g/mol
VQ-034384
1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride
- CAS
- 1228879-37-5
- Formula
- C14H24Cl2N2
- MW
- 291.3 g/mol
VQ-042582
2-Cyano-N-cyclopropyl-N-((2-fluoro-4-iodophenyl)carbamoyl)acetamide
- CAS
- 871700-26-4
- Formula
- C13H11FIN3O2
- MW
- 387.15 g/mol
VQ-034379
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate chemical structure](/media/structures/RCCOZJPSLZNDFV-UHFFFAOYSA-N.svg)
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
- CAS
- 871700-32-2
- Formula
- C25H21FIN3O6S
- MW
- 637.4 g/mol
VQ-042642
6-Amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyrimidine-2,4(1H,3H)-dione
- CAS
- 871700-28-6
- Formula
- C13H11FIN3O2
- MW
- 387.15 g/mol
VQ-034380
![N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide chemical structure](/media/structures/VZGZVUHKJNLAQX-UHFFFAOYSA-N.svg)
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
- CAS
- 1383430-04-3
- Formula
- C26H23FIN5O6
- MW
- 647.4 g/mol
VQ-034382
![N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide chemical structure](/media/structures/PZDRAVCDHCXECY-UHFFFAOYSA-N.svg)
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
- CAS
- 1383430-03-2
- Formula
- C26H23FIN5O5
- MW
- 631.4 g/mol
VQ-034381
FAQs — Trametinib impurities
Which Trametinib impurities do you supply?
We list 27 Trametinib-related reference materials, including process impurities, degradation products, nitrosamine impurities, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Trametinib impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Trametinib impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Trametinib impurity standards
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