Trametinib Nitro impurity

Name: Trametinib Nitro impurity
Brand: Vaqora Chemicals
SKU: VQ-028474

About Trametinib Nitro impurity

Trametinib Nitro impurity is an impurity of Trametinib carrying the CAS registry number 1279693-89-8. Its molecular formula is C24H19FIN5O5 and its molecular weight is 603.3 g/mol. Systematically, it is named 3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7-trione.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Trametinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Trametinib Nitro impurity in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Trametinib

View every impurity, metabolite and intermediate we list for Trametinib.

Trametinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Trametinib Nitro impurity
Catalogue No.	VQ-028474
CAS Number	1279693-89-8
IUPAC name	3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7-trione
Molecular formula	C₂₄H₁₉FIN₅O₅
Molecular weight	603.3 g/mol
Exact mass	603.0415
Grade	Reference Standard
HSN code	38229090
InChIKey	VKGYKKVZKDYUBY-UHFFFAOYSA-N
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)[N+](=O)[O-])C5CC5
PubChem CID	91666254

Physical properties
Physical form	Solid
LogP (XLogP3)	4.1
H-bond donors / acceptors	1 / 7
TPSA	119 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trametinib Nitro impurity?

The CAS Registry Number of Trametinib Nitro impurity is 1279693-89-8.

What is the molecular formula and molecular weight of Trametinib Nitro impurity?

Trametinib Nitro impurity has the molecular formula C24H19FIN5O5 and a molecular weight of 603.3 g/mol. Its IUPAC name is 3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7-trione.

What is Trametinib Nitro impurity used for?

Trametinib Nitro impurity is supplied as a characterised reference material related to Trametinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trametinib Nitro impurity can I order?

We supply Trametinib Nitro impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trametinib Nitro impurity?

Yes. Every lot of Trametinib Nitro impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trametinib Nitro impurity be shipped internationally?

Yes. We export Trametinib Nitro impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.