Trimethoprim-d9

Name: Trimethoprim-d9
Brand: Vaqora Chemicals
SKU: VQ-042705

About Trimethoprim-d9

Trimethoprim-d9 is a stable isotope labelled analogue related to Trimethoprim carrying the CAS registry number 1189460-62-5. Its molecular formula is C14H18N4O3 and its molecular weight is 299.37 g/mol. Systematically, it is named 5-[[3,4,5-tris(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine. Common synonyms include Trimethoprim-d9 (Major) and TMID-0479.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Trimethoprim and related analytes in bioanalytical, pharmacokinetic and impurity studies. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Trimethoprim-d9 is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Trimethoprim

View every impurity, metabolite and intermediate we list for Trimethoprim.

Trimethoprim impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Trimethoprim-d9
Catalogue No.	VQ-042705
CAS Number	1189460-62-5
IUPAC name	5-[[3,4,5-tris(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine
Molecular formula	C₁₄H₁₈N₄O₃
Molecular weight	299.37 g/mol
Exact mass	299.1944
Grade	Reference Standard
HSN code	38229090
InChIKey	IEDVJHCEMCRBQM-GQALSZNTSA-N
SMILES	[2H]C([2H])([2H])OC1=CC(=CC(=C1OC([2H])([2H])[2H])OC([2H])([2H])[2H])CC2=CN=C(N=C2N)N
PubChem CID	45040631

Physical properties
Physical form	Solid
LogP (XLogP3)	0.9
H-bond donors / acceptors	2 / 7
TPSA	106 Å²
Synonyms	Trimethoprim-d9 (Major), 5-((3,4,5-Tris(trideuteriomethoxy)phenyl)methyl)pyrimidine-2,4-diamine, TMID-0479, 2,4-Diamino-5-(3,4,5-tri(methoxy-d3)benzyl)pyrimidine, 5-({3,4,5-Tris[(~2~H_3_)methyloxy]phenyl}methyl)pyrimidine-2,4-diamine

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trimethoprim-d9?

The CAS Registry Number of Trimethoprim-d9 is 1189460-62-5. It is also known as Trimethoprim-d9 (Major), 5-((3,4,5-Tris(trideuteriomethoxy)phenyl)methyl)pyrimidine-2,4-diamine, TMID-0479.

What is the molecular formula and molecular weight of Trimethoprim-d9?

Trimethoprim-d9 has the molecular formula C14H18N4O3 and a molecular weight of 299.37 g/mol. Its IUPAC name is 5-[[3,4,5-tris(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine.

What is Trimethoprim-d9 used for?

Trimethoprim-d9 is supplied as a characterised reference material related to Trimethoprim. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trimethoprim-d9 can I order?

We supply Trimethoprim-d9 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trimethoprim-d9?

Yes. Every lot of Trimethoprim-d9 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trimethoprim-d9 be shipped internationally?

Yes. Trimethoprim-d9 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.