Tert-Butyl 2,6-dichloronicotinate

Name: Tert-Butyl 2,6-dichloronicotinate
Brand: Vaqora Chemicals
SKU: VQ-044592

About Tert-Butyl 2,6-dichloronicotinate

Tert-Butyl 2,6-dichloronicotinate (CAS 1013647-75-0) is an impurity of Elexacaftor offered by Vaqora Chemicals. With the molecular formula C10H11Cl2NO2, it has a molar mass of 248.1 g/mol. The IUPAC name is tert-butyl 2,6-dichloropyridine-3-carboxylate. It is also known as 2,6-Dichloro-nicotinic acid tert-butyl ester or 2,6-Dichloronicotinic acid tert-butyl ester.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Elexacaftor to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Elexacaftor

View every impurity, metabolite and intermediate we list for Elexacaftor.

Elexacaftor impurities

Specifications & identifiers

Chemical identifiers
Product name	Tert-Butyl 2,6-dichloronicotinate
Catalogue No.	VQ-044592
CAS Number	1013647-75-0
IUPAC name	tert-butyl 2,6-dichloropyridine-3-carboxylate
Molecular formula	C₁₀H₁₁Cl₂NO₂
Molecular weight	248.1 g/mol
Exact mass	247.0167
Grade	Reference Standard
HSN code	38229090
InChIKey	GTWXYRAFRYVGNS-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)C1=C(N=C(C=C1)Cl)Cl
PubChem CID	59830733

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	0 / 3
TPSA	39.2 Å²
Synonyms	2,6-Dichloro-nicotinic acid tert-butyl ester, 2,6-Dichloronicotinic acid tert-butyl ester, 2,6-Dichloronicotinic acidtBu ester, tert-butyl 2,6-dichloropyridine-3-carboxylate - [B81106], 3-Pyridinecarboxylic acid, 2,6-dichloro-, 1,1-dimethylethyl ester

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tert-Butyl 2,6-dichloronicotinate?

The CAS Registry Number of Tert-Butyl 2,6-dichloronicotinate is 1013647-75-0. It is also known as 2,6-Dichloro-nicotinic acid tert-butyl ester, 2,6-Dichloronicotinic acid tert-butyl ester, 2,6-Dichloronicotinic acidtBu ester.

What is the molecular formula and molecular weight of Tert-Butyl 2,6-dichloronicotinate?

Tert-Butyl 2,6-dichloronicotinate has the molecular formula C10H11Cl2NO2 and a molecular weight of 248.1 g/mol. Its IUPAC name is tert-butyl 2,6-dichloropyridine-3-carboxylate.

What is Tert-Butyl 2,6-dichloronicotinate used for?

Tert-Butyl 2,6-dichloronicotinate is supplied as a characterised reference material related to Elexacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tert-Butyl 2,6-dichloronicotinate can I order?

We supply Tert-Butyl 2,6-dichloronicotinate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tert-Butyl 2,6-dichloronicotinate?

Yes. Every lot of Tert-Butyl 2,6-dichloronicotinate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tert-Butyl 2,6-dichloronicotinate be shipped internationally?

Yes. Tert-Butyl 2,6-dichloronicotinate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.