1-BOC-4-hydroxypiperidine

Name: 1-BOC-4-hydroxypiperidine
Brand: Vaqora Chemicals
SKU: VQ-037615

About 1-BOC-4-hydroxypiperidine

1-BOC-4-hydroxypiperidine is a metabolite or degradation product of Ibrutinib carrying the CAS registry number 109384-19-2. The compound has the formula C10H19NO3, corresponding to a molecular weight of 201.26 g/mol. The IUPAC name is tert-butyl 4-hydroxypiperidine-1-carboxylate. Common synonyms include n-boc-4-hydroxypiperidine and 1-Boc-4-piperidinol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Ibrutinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 1-BOC-4-hydroxypiperidine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ibrutinib

View every impurity, metabolite and intermediate we list for Ibrutinib.

Ibrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	1-BOC-4-hydroxypiperidine
Catalogue No.	VQ-037615
CAS Number	109384-19-2
IUPAC name	tert-butyl 4-hydroxypiperidine-1-carboxylate
Molecular formula	C₁₀H₁₉NO₃
Molecular weight	201.26 g/mol
Exact mass	201.1365
Grade	Reference Standard
HSN code	38229090
InChIKey	PWQLFIKTGRINFF-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCC(CC1)O
PubChem CID	643502

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	1 / 3
TPSA	49.8 Å²
Synonyms	4-Hydroxypiperidine-1-carboxylic acid tert-butyl ester, n-boc-4-hydroxypiperidine, 1-Boc-4-piperidinol, N-Boc-4-piperidinol, 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine, 1-piperidinecarboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester, Boc-(4-hydroxy)piperidine, 1-tert-Butoxycarbonyl-4-hydroxypiperidine, 1-Boc-piperidin-4-ol, 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-BOC-4-hydroxypiperidine?

The CAS Registry Number of 1-BOC-4-hydroxypiperidine is 109384-19-2. It is also known as 4-Hydroxypiperidine-1-carboxylic acid tert-butyl ester, n-boc-4-hydroxypiperidine, 1-Boc-4-piperidinol.

What is the molecular formula and molecular weight of 1-BOC-4-hydroxypiperidine?

1-BOC-4-hydroxypiperidine has the molecular formula C10H19NO3 and a molecular weight of 201.26 g/mol. Its IUPAC name is tert-butyl 4-hydroxypiperidine-1-carboxylate.

What is 1-BOC-4-hydroxypiperidine used for?

1-BOC-4-hydroxypiperidine is supplied as a characterised reference material related to Ibrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-BOC-4-hydroxypiperidine can I order?

We supply 1-BOC-4-hydroxypiperidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-BOC-4-hydroxypiperidine?

Yes. Every lot of 1-BOC-4-hydroxypiperidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-BOC-4-hydroxypiperidine be shipped internationally?

Yes. 1-BOC-4-hydroxypiperidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.