Amitriptyline EP Impurity F

Name: Amitriptyline EP Impurity F
Brand: Vaqora Chemicals
SKU: VQ-029125

About Amitriptyline EP Impurity F

Amitriptyline EP Impurity F (CAS 1159-82-6) is a pharmacopeial impurity of Amitriptyline offered by Vaqora Chemicals. The compound has the formula C20H23NO, corresponding to a molecular weight of 293.4 g/mol. Its systematic (IUPAC) name is 2-[3-(dimethylamino)propylidene]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-9-ol. Alternative names: 10-Hydroxy Amitriptyline and 10-Hydroxyamitriptyline.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Amitriptyline to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Amitriptyline

View every impurity, metabolite and intermediate we list for Amitriptyline.

Amitriptyline impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Amitriptyline EP Impurity F
Catalogue No.	VQ-029125
CAS Number	1159-82-6
IUPAC name	2-[3-(dimethylamino)propylidene]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-9-ol
Molecular formula	C₂₀H₂₃NO
Molecular weight	293.4 g/mol
Exact mass	293.178
Grade	Reference Standard
HSN code	38229090
InChIKey	GHWBJXOKAFHZAI-UHFFFAOYSA-N
SMILES	CN(C)CCC=C1C2=CC=CC=C2CC(C3=CC=CC=C31)O
PubChem CID	155720

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	1 / 2
TPSA	23.5 Å²
Synonyms	10-Hydroxy Amitriptyline, Amitriptyline Hydrochloride - Impurity F (Freebase), 10-Hydroxyamitriptyline, 5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (5EZ,10RS)-5-[3-(Dimethyl-amino)propylidene]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol, hydroxyamitriptyline, Hydroxy-amitriptyline, 10-, Amitriptylin-M (E)-10-hydroxy, 5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Amitriptyline EP Impurity F?

The CAS Registry Number of Amitriptyline EP Impurity F is 1159-82-6. It is also known as 10-Hydroxy Amitriptyline, Amitriptyline Hydrochloride - Impurity F (Freebase), 10-Hydroxyamitriptyline.

What is the molecular formula and molecular weight of Amitriptyline EP Impurity F?

Amitriptyline EP Impurity F has the molecular formula C20H23NO and a molecular weight of 293.4 g/mol. Its IUPAC name is 2-[3-(dimethylamino)propylidene]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-9-ol.

What is Amitriptyline EP Impurity F used for?

Amitriptyline EP Impurity F is supplied as a characterised reference material related to Amitriptyline. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Amitriptyline EP Impurity F can I order?

We supply Amitriptyline EP Impurity F in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Amitriptyline EP Impurity F?

Yes. Every lot of Amitriptyline EP Impurity F is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Amitriptyline EP Impurity F be shipped internationally?

Yes. Amitriptyline EP Impurity F is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.