Duloxetine

About Duloxetine

Duloxetine is a high-purity reference standard of Duloxetine carrying the CAS registry number 116539-59-4. The compound has the formula C18H19NOS, corresponding to a molecular weight of 297.4 g/mol. The IUPAC name is (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine. Common synonyms include (+)-Duloxetine and (S)-Duloxetine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Duloxetine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Duloxetine

View every impurity, metabolite and intermediate we list for Duloxetine.

Duloxetine impurities

Specifications & identifiers

Chemical identifiers
Product name	Duloxetine
Catalogue No.	VQ-007441
CAS Number	116539-59-4
IUPAC name	(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
Molecular formula	C₁₈H₁₉NOS
Molecular weight	297.4 g/mol
Exact mass	297.1187
Grade	Reference Standard
HSN code	38229090
InChIKey	ZEUITGRIYCTCEM-KRWDZBQOSA-N
SMILES	CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
PubChem CID	60835

Physical properties
Physical form	Solid
LogP (XLogP3)	4.3
H-bond donors / acceptors	1 / 3
TPSA	49.5 Å²
Synonyms	(+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, (+)-Duloxetine, (S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine, (S)-Duloxetine, (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, Ariclaim, 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaS)-, (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine, (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine, 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (S)-, methyl((3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl)amine

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Duloxetine?

The CAS Registry Number of Duloxetine is 116539-59-4. It is also known as (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, (+)-Duloxetine, (S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine.

What is the molecular formula and molecular weight of Duloxetine?

Duloxetine has the molecular formula C18H19NOS and a molecular weight of 297.4 g/mol. Its IUPAC name is (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine.

What is Duloxetine used for?

Duloxetine is supplied as a characterised reference material related to Duloxetine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Duloxetine can I order?

We supply Duloxetine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Duloxetine?

Yes. Every lot of Duloxetine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Duloxetine be shipped internationally?

Yes. Duloxetine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.