Levonebivolol

Name: Levonebivolol
Brand: Vaqora Chemicals
SKU: VQ-026839

About Levonebivolol

Listed under CAS 118457-16-2, Levonebivolol is an impurity of Nebivolol available from Vaqora Chemicals. Its molecular formula is C22H25F2NO4 and its molecular weight is 405.4 g/mol. Common synonyms include (R,S,S,S)-Nebivolol and (-)-Nebivolol.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Nebivolol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Levonebivolol in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	Levonebivolol
Catalogue No.	VQ-026839
CAS Number	118457-16-2
IUPAC name	(1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
Molecular formula	C₂₂H₂₅F₂NO₄
Molecular weight	405.4 g/mol
Exact mass	405.1752
Grade	Reference Standard
HSN code	38229090
InChIKey	KOHIRBRYDXPAMZ-YHDSQAASSA-N
SMILES	C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H](CNC[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O
PubChem CID	9844194

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	3 / 7
TPSA	71 Å²
Synonyms	(R,S,S,S)-Nebivolol, (-)-Nebivolol, l-nebivolol, (-)-SSSR-nebivolol, (1S,1'S)-2,2'-iminobis{1-[(2R,2'S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol}, rel-Nebivolol, RSSS-Nebivolol, L-Nebivolol (RS,SS)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Levonebivolol?

The CAS Registry Number of Levonebivolol is 118457-16-2. It is also known as (R,S,S,S)-Nebivolol, (-)-Nebivolol, l-nebivolol.

What is the molecular formula and molecular weight of Levonebivolol?

Levonebivolol has the molecular formula C22H25F2NO4 and a molecular weight of 405.4 g/mol. Its IUPAC name is (1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol.

What is Levonebivolol used for?

Levonebivolol is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Levonebivolol can I order?

We supply Levonebivolol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Levonebivolol?

Yes. Every lot of Levonebivolol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Levonebivolol be shipped internationally?

Yes. We export Levonebivolol worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.