Macitentan Tert-butoxypyrimidine Impurity

About Macitentan Tert-butoxypyrimidine Impurity

Macitentan Tert-butoxypyrimidine Impurity is an impurity of Macitentan carrying the CAS registry number 121487-13-6. The compound has the formula C8H11BrN2O, corresponding to a molecular weight of 231.09 g/mol. Systematically, it is named 5-bromo-2-[(2-methylpropan-2-yl)oxy]pyrimidine. Common synonyms include 5-Bromo-2-tert-butoxypyrimidine and 5-Bromo-2-tert-butoxy-pyrimidine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Macitentan, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	Macitentan Tert-butoxypyrimidine Impurity
Catalogue No.	VQ-052110
CAS Number	121487-13-6
IUPAC name	5-bromo-2-[(2-methylpropan-2-yl)oxy]pyrimidine
Molecular formula	C₈H₁₁BrN₂O
Molecular weight	231.09 g/mol
Exact mass	230.0055
Grade	Reference Standard
HSN code	38229090
InChIKey	UPKQXRBCDUBUTI-UHFFFAOYSA-N
SMILES	CC(C)(C)OC1=NC=C(C=N1)Br
PubChem CID	14242657

Physical properties
Physical form	Solid
LogP (XLogP3)	2.2
H-bond donors / acceptors	0 / 3
TPSA	35 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Macitentan Tert-butoxypyrimidine Impurity?

The CAS Registry Number of Macitentan Tert-butoxypyrimidine Impurity is 121487-13-6. It is also known as 5-Bromo-2-tert-butoxypyrimidine, 5-Bromo-2-tert-butoxy-pyrimidine, Pyrimidine, 5-bromo-2-(1,1-dimethylethoxy)-.

What is the molecular formula and molecular weight of Macitentan Tert-butoxypyrimidine Impurity?

Macitentan Tert-butoxypyrimidine Impurity has the molecular formula C8H11BrN2O and a molecular weight of 231.09 g/mol. Its IUPAC name is 5-bromo-2-[(2-methylpropan-2-yl)oxy]pyrimidine.

What is Macitentan Tert-butoxypyrimidine Impurity used for?

Macitentan Tert-butoxypyrimidine Impurity is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Macitentan Tert-butoxypyrimidine Impurity can I order?

We supply Macitentan Tert-butoxypyrimidine Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Macitentan Tert-butoxypyrimidine Impurity?

Yes. Every lot of Macitentan Tert-butoxypyrimidine Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Macitentan Tert-butoxypyrimidine Impurity be shipped internationally?

Yes. Macitentan Tert-butoxypyrimidine Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.