Anastrozole EP Impurity A

Name: Anastrozole EP Impurity A
Brand: Vaqora Chemicals
SKU: VQ-006238

About Anastrozole EP Impurity A

Vaqora Chemicals supplies Anastrozole EP Impurity A, a pharmacopeial impurity of Anastrozole registered under CAS number 1215780-15-6, specified at 91.4% purity. The compound has the formula C16H17N5, corresponding to a molecular weight of 279.34 g/mol. The IUPAC name is 2-[3-(1-cyanoethyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile. Common synonyms include Desmethyl Anastrozole and alpha-Desmethyl Anastrozole.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Anastrozole to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Anastrozole EP Impurity A in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Anastrozole

View every impurity, metabolite and intermediate we list for Anastrozole.

Anastrozole impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Anastrozole EP Impurity A
Catalogue No.	VQ-006238
CAS Number	1215780-15-6
IUPAC name	2-[3-(1-cyanoethyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
Molecular formula	C₁₆H₁₇N₅
Molecular weight	279.34 g/mol
Exact mass	279.1484
Grade	Reference Standard
Purity / assay	91.4%
HSN code	38229090
InChIKey	LXXANTDQIIXQBZ-UHFFFAOYSA-N
SMILES	CC(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N
PubChem CID	57149578

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	0 / 4
TPSA	78.3 Å²
Synonyms	α1,α1,α3-Trimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile, Desmethyl Anastrozole, alpha-Desmethyl Anastrozole, 2-[3-(1-cyanoethyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]phenyl]-2-methylpropanenitrile, 2-(3-(1-cyanoethyl)-5-((1H-1,2,4-triazol-1-yl)methyl)phenyl)-2-methylpropanenitrile, 2-{3-(1-Cyanoethyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]phenyl}-2-methylpropanenitrile, Anastrozole Impurity B, 2-(3-((1H-1,2,4-Triazol-1-yl)methyl)-5-(1-cyanoethyl)phenyl)-2-methylpropanenitrile, a-Desmethyl Anastrozole(>90%), 2-(3-((1RS)-1-Cyanoethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl)-2-methylpropanenitrile, 2-(3-(1-Cyanoethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl)-2-methylpropionitrile, 2-[3-[(1RS)-1-Cyanoethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

Safety & hazard information (GHS)

Toxic

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H331Toxic if inhaled
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P263, P264, P270, P271, P273, P280, P301 + P316, P304 + P340, P316, P318, P319, P321, P330, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Anastrozole EP Impurity A?

The CAS Registry Number of Anastrozole EP Impurity A is 1215780-15-6. It is also known as α1,α1,α3-Trimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile, Desmethyl Anastrozole, alpha-Desmethyl Anastrozole.

What is the molecular formula and molecular weight of Anastrozole EP Impurity A?

Anastrozole EP Impurity A has the molecular formula C16H17N5 and a molecular weight of 279.34 g/mol. Its IUPAC name is 2-[3-(1-cyanoethyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile.

What is Anastrozole EP Impurity A used for?

Anastrozole EP Impurity A is supplied as a characterised reference material related to Anastrozole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Anastrozole EP Impurity A can I order?

We supply Anastrozole EP Impurity A in Reference Standard (91.4%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Anastrozole EP Impurity A?

Yes. Every lot of Anastrozole EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Anastrozole EP Impurity A be shipped internationally?

Yes. Anastrozole EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.