6-Alpha Hydroxyestradiol

Name: 6-Alpha Hydroxyestradiol
Brand: Vaqora Chemicals
SKU: VQ-022563

About 6-Alpha Hydroxyestradiol

Listed under CAS 1229-24-9, 6-Alpha Hydroxyestradiol is a metabolite or degradation product of Estradiol available from Vaqora Chemicals. The compound has the formula C18H24O3, corresponding to a molecular weight of 288.4 g/mol. Its systematic (IUPAC) name is (6S,8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6,17-triol. It is also known as 6α-Hydroxyestradiol or 6alpha-hydroxy-17beta-estradiol.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 7 hazard statements. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Estradiol, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 6-Alpha Hydroxyestradiol is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Estradiol

View every impurity, metabolite and intermediate we list for Estradiol.

Estradiol impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Alpha Hydroxyestradiol
Catalogue No.	VQ-022563
CAS Number	1229-24-9
IUPAC name	(6S,8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6,17-triol
Molecular formula	C₁₈H₂₄O₃
Molecular weight	288.4 g/mol
Exact mass	288.1725
Grade	Reference Standard
HSN code	38229090
InChIKey	QZZRQURPSRWTLG-WOVZSMEKSA-N
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)C[C@@H](C4=C3C=CC(=C4)O)O
PubChem CID	5284655

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	3 / 3
TPSA	60.7 Å²
Synonyms	6α-Hydroxyestradiol, 6alpha-hydroxy-17beta-estradiol, estra-1,3,5(10)-triene-3,6alpha,17beta-triol, Estra-1,3,5(10)-triene-3,6,17-triol, (6alpha,17beta)-, Estra-1,3,5(10)-triene-3,6,17-triol, (6.alpha.,17.beta.)-, 6a-Hydroxy 17b-Estradiol, 6, A-Hydroxyestradiol, 6alpha-Hydroxy 17beta-Estradiol, Opera_ID_1884

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Alpha Hydroxyestradiol?

The CAS Registry Number of 6-Alpha Hydroxyestradiol is 1229-24-9. It is also known as 6α-Hydroxyestradiol, 6alpha-hydroxy-17beta-estradiol, estra-1,3,5(10)-triene-3,6alpha,17beta-triol.

What is the molecular formula and molecular weight of 6-Alpha Hydroxyestradiol?

6-Alpha Hydroxyestradiol has the molecular formula C18H24O3 and a molecular weight of 288.4 g/mol. Its IUPAC name is (6S,8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6,17-triol.

What is 6-Alpha Hydroxyestradiol used for?

6-Alpha Hydroxyestradiol is supplied as a characterised reference material related to Estradiol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Alpha Hydroxyestradiol can I order?

We supply 6-Alpha Hydroxyestradiol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Alpha Hydroxyestradiol?

Yes. Every lot of 6-Alpha Hydroxyestradiol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Alpha Hydroxyestradiol be shipped internationally?

Yes. 6-Alpha Hydroxyestradiol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.