Hydroxymethyl Ivacaftor

Name: Hydroxymethyl Ivacaftor
Brand: Vaqora Chemicals
SKU: VQ-026269

About Hydroxymethyl Ivacaftor

Vaqora Chemicals supplies Hydroxymethyl Ivacaftor, a metabolite or degradation product of Ivacaftor registered under CAS number 1246213-23-9. The compound has the formula C24H28N2O4, corresponding to a molecular weight of 408.5 g/mol. Systematically, it is named N-[2-tert-butyl-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-4-oxo-1H-quinoline-3-carboxamide. Alternative names: Ivacaftor (m1).

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Ivacaftor, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ivacaftor

View every impurity, metabolite and intermediate we list for Ivacaftor.

Ivacaftor impurities

Specifications & identifiers

Chemical identifiers
Product name	Hydroxymethyl Ivacaftor
Catalogue No.	VQ-026269
CAS Number	1246213-23-9
IUPAC name	N-[2-tert-butyl-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-4-oxo-1H-quinoline-3-carboxamide
Molecular formula	C₂₄H₂₈N₂O₄
Molecular weight	408.5 g/mol
Exact mass	408.2049
Grade	Reference Standard
HSN code	38229090
InChIKey	HFNOECBPRSJRQD-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)CO
PubChem CID	46897962

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	4 / 5
TPSA	98.7 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Hydroxymethyl Ivacaftor?

The CAS Registry Number of Hydroxymethyl Ivacaftor is 1246213-23-9. It is also known as Ivacaftor (m1).

What is the molecular formula and molecular weight of Hydroxymethyl Ivacaftor?

Hydroxymethyl Ivacaftor has the molecular formula C24H28N2O4 and a molecular weight of 408.5 g/mol. Its IUPAC name is N-[2-tert-butyl-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-4-oxo-1H-quinoline-3-carboxamide.

What is Hydroxymethyl Ivacaftor used for?

Hydroxymethyl Ivacaftor is supplied as a characterised reference material related to Ivacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Hydroxymethyl Ivacaftor can I order?

We supply Hydroxymethyl Ivacaftor in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Hydroxymethyl Ivacaftor?

Yes. Every lot of Hydroxymethyl Ivacaftor is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Hydroxymethyl Ivacaftor be shipped internationally?

Yes. Hydroxymethyl Ivacaftor is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.