4-epi-Dolutegravir

About 4-epi-Dolutegravir

4-epi-Dolutegravir is a process intermediate or related compound of Dolutegravir carrying the CAS registry number 1357289-37-2, specified at 99.84% purity. Its molecular formula is C20H19F2N3O5 and its molecular weight is 419.4 g/mol. It is also known as Dolutegravir 4- Epimer or dolutegravir S,S-.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

It is a process intermediate or related compound in the synthesis of Dolutegravir, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-epi-Dolutegravir is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Dolutegravir

View every impurity, metabolite and intermediate we list for Dolutegravir.

Dolutegravir impurities

Specifications & identifiers

Chemical identifiers
Product name	4-epi-Dolutegravir
Catalogue No.	VQ-013102
CAS Number	1357289-37-2
IUPAC name	(3S,7S)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
Molecular formula	C₂₀H₁₉F₂N₃O₅
Molecular weight	419.4 g/mol
Exact mass	419.1293
Grade	Reference Standard
Purity / assay	99.84%
HSN code	2933
InChIKey	RHWKPHLQXYSBKR-BONVTDFDSA-N
SMILES	C[C@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
PubChem CID	117853645

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	2 / 8
TPSA	99.2 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-epi-Dolutegravir?

The CAS Registry Number of 4-epi-Dolutegravir is 1357289-37-2. It is also known as Dolutegravir 4- Epimer, dolutegravir S,S-, Dolutegravir S,S-isomer.

What is the molecular formula and molecular weight of 4-epi-Dolutegravir?

4-epi-Dolutegravir has the molecular formula C20H19F2N3O5 and a molecular weight of 419.4 g/mol. Its IUPAC name is (3S,7S)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide.

What is 4-epi-Dolutegravir used for?

4-epi-Dolutegravir is supplied as a characterised reference material related to Dolutegravir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-epi-Dolutegravir can I order?

We supply 4-epi-Dolutegravir in Reference Standard (99.84%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-epi-Dolutegravir?

Yes. Every lot of 4-epi-Dolutegravir is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-epi-Dolutegravir be shipped internationally?

Yes. We export 4-epi-Dolutegravir worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.