(S,S)-Palonosetron

About (S,S)-Palonosetron

(S,S)-Palonosetron is an impurity of Palonosetron carrying the CAS registry number 135729-61-2. Its molecular formula is C19H24N2O and its molecular weight is 296.4 g/mol. Its systematic (IUPAC) name is (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one. It is also known as Palonosetron or (-)-Palonosetron.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

This Palonosetron impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer (S,S)-Palonosetron in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Palonosetron

View every impurity, metabolite and intermediate we list for Palonosetron.

Palonosetron impurities

Specifications & identifiers

Chemical identifiers
Product name	(S,S)-Palonosetron
Catalogue No.	VQ-004285
CAS Number	135729-61-2
Other CAS	135729-62-3, 1021481-17-3
IUPAC name	(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one
Molecular formula	C₁₉H₂₄N₂O
Molecular weight	296.4 g/mol
Exact mass	296.1889
Grade	Reference Standard
HSN code	38229090
InChIKey	CPZBLNMUGSZIPR-NVXWUHKLSA-N
SMILES	C1C[C@@H]2CN(C(=O)C3=CC=CC(=C23)C1)[C@@H]4CN5CCC4CC5
PubChem CID	6337614

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	0 / 2
TPSA	23.6 Å²
Synonyms	(S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one, Palonosetron, (-)-Palonosetron, (S,S)-Palonosetron, 2-Qhbiqo, Palonosetron, (3as, 3s)-, 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, Palonosetron (INN), Aloxi, Ritanine (fosrolapitant + palonosetron), (3aS)-2-[(3S)-quinuclidin-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S,S)-Palonosetron?

The CAS Registry Number of (S,S)-Palonosetron is 135729-61-2. It is also known as (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one, Palonosetron, (-)-Palonosetron.

What is the molecular formula and molecular weight of (S,S)-Palonosetron?

(S,S)-Palonosetron has the molecular formula C19H24N2O and a molecular weight of 296.4 g/mol. Its IUPAC name is (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one.

What is (S,S)-Palonosetron used for?

(S,S)-Palonosetron is supplied as a characterised reference material related to Palonosetron. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S,S)-Palonosetron can I order?

We supply (S,S)-Palonosetron in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S,S)-Palonosetron?

Yes. Every lot of (S,S)-Palonosetron is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S,S)-Palonosetron be shipped internationally?

Yes. We export (S,S)-Palonosetron worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.