O-Desmethyl apremilast

About O-Desmethyl apremilast

O-Desmethyl apremilast is a metabolite or degradation product of Apremilast carrying the CAS registry number 1384441-38-6. The compound has the formula C21H22N2O7S, corresponding to a molecular weight of 446.5 g/mol. Systematically, it is named N-[2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide. Alternative names: Apremilast O-Desmethyl and 4-Hydroxy-Apremilast.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Apremilast, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, O-Desmethyl apremilast is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Apremilast

View every impurity, metabolite and intermediate we list for Apremilast.

Apremilast impurities

Specifications & identifiers

Chemical identifiers
Product name	O-Desmethyl apremilast
Catalogue No.	VQ-021609
CAS Number	1384441-38-6
IUPAC name	N-[2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
Molecular formula	C₂₁H₂₂N₂O₇S
Molecular weight	446.5 g/mol
Exact mass	446.1148
Grade	Reference Standard
HSN code	38229090
InChIKey	PEUJABWEZWJNBO-MRXNPFEDSA-N
SMILES	CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)O
PubChem CID	68088610

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	2 / 7
TPSA	138 Å²
Synonyms	Apremilast O-Desmethyl, 4-Hydroxy-Apremilast, O-Demethyl apremilast, Apremilast (m3), O-Desmethylapremilast (M3)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of O-Desmethyl apremilast?

The CAS Registry Number of O-Desmethyl apremilast is 1384441-38-6. It is also known as Apremilast O-Desmethyl, 4-Hydroxy-Apremilast, O-Demethyl apremilast.

What is the molecular formula and molecular weight of O-Desmethyl apremilast?

O-Desmethyl apremilast has the molecular formula C21H22N2O7S and a molecular weight of 446.5 g/mol. Its IUPAC name is N-[2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide.

What is O-Desmethyl apremilast used for?

O-Desmethyl apremilast is supplied as a characterised reference material related to Apremilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of O-Desmethyl apremilast can I order?

We supply O-Desmethyl apremilast in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with O-Desmethyl apremilast?

Yes. Every lot of O-Desmethyl apremilast is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can O-Desmethyl apremilast be shipped internationally?

Yes. We export O-Desmethyl apremilast worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.